Results 61 to 70 of about 301,938 (261)

Evaluating Jordan's antimicrobial resistance national action plan (2018–2022) implementation: progress and recommendations

BMC Public Health
Background Antimicrobial resistance (AMR) is a pressing global public health challenge that requires coordinated multi-sectoral responses under the One Health framework.
Salam Momani, Mohammad S. Alyahya, Dalia K. Zayed, Ala Bin Tarif, Omar F. Nimri, Sami Alshaikh, Adel Belbiesi, Ala’a B. Al-Tammemi   +7 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Тhe role of municipalities in implementing the national plan for cardiovascular health. Тhe example of the municipality of Тroyan for the prevention of CVD through rational nutrition of children and mass sports [PDF]

Българска кардиология
The first step in the successful implementation of the National Plan for Cardiovascular Health is the education of children and adolescents on proper nutrition and physical activity.
K. Marinov, I. Gruev
doaj   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Evaluating the implementation of Sierra Leone’s first National Action Plan for Health Security, 2018–2024: lessons learnt and way forward

Frontiers in Tropical Diseases
IntroductionThe Parties Self-Assessment Annual Reporting (SPAR) and Joint External Evaluations (JEE) enable countries to assess their capabilities in handling public health threats and addressing gaps through the National Action Plan for Health Security (
Bobson Derrick Fofanah, Foday Sahr, Robert Musoke, Charles Njuguna, Mohamed Vandi, Mustapha Jalloh, James Sylvester Squire, Medlin Soko Tucker, Michael Ndolie, Victor Caulker, Joseph Sam Kanu, Mohamed Boie Jalloh, Stephen Sesay, Ibrahim Franklyn Kamara, Sulaiman Lakoh, Saidu Bamayange, Osman Baimba Koroma, George Ameh   +17 more
doaj   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Preparing for the EU HTA Regulation: Insights from the Dutch Perspective

Journal of Market Access & Health Policy
The European Health Technology Assessment (HTA) regulation (HTAR) came into effect in January 2025 and impacts the HTA process in all European Member States. Member States must give due consideration to the joint clinical assessment (JCA) report.
Anne Willemsen, Maureen Rutten-van Mölken, Riam al Dulaimi, Hedi Schelleman, Wim Goettsch, Lonneke Timmers   +5 more
doaj   +1 more source