Results 91 to 100 of about 964,883 (379)

Revealing speckle obscured living human retinal cells with artificial intelligence assisted adaptive optics optical coherence tomography

Communications Medicine
Background In vivo imaging of the human retina using adaptive optics optical coherence tomography (AO-OCT) has transformed medical imaging by enabling visualization of 3D retinal structures at cellular-scale resolution, including the retinal pigment ...
Vineeta Das, Furu Zhang, Andrew J. Bower, Joanne Li, Tao Liu, Nancy Aguilera, Bruno Alvisio, Zhuolin Liu, Daniel X. Hammer, Johnny Tam   +9 more
doaj   +1 more source

Intra-Amniotic Infection with Ureaplasma parvum Causes Preterm Birth and Neonatal Mortality That Are Prevented by Treatment with Clarithromycin

mBio, 2020
Intra-amniotic infection is strongly associated with adverse pregnancy and neonatal outcomes. Most intra-amniotic infections are due to Ureaplasma species; however, the pathogenic potency of these genital mycoplasmas to induce preterm birth is still ...
Kenichiro Motomura, Roberto Romero, Yi Xu, Kevin R. Theis, Jose Galaz, Andrew D. Winters, Rebecca Slutsky, Valeria Garcia-Flores, Chengrui Zou, Dustyn Levenson, Robert Para, Madison M. Ahmad, Derek Miller, Chaur-Dong Hsu, Nardhy Gomez-Lopez   +14 more
doaj   +1 more source

Gene therapy for rare diseases: summary of a National Institutes of Health workshop, September 13, 2012.

Human Gene Therapy, 2013
Gene therapy has shown clinical efficacy for several rare diseases, using different approaches and vectors. The Gene Therapy for Rare Diseases workshop, sponsored by the National Institutes of Health (NIH) Office of Biotechnology Activities and Office of
Marina O’reilly, D. Kohn, J. Bartlett, Janet M. Benson, P. J. Brooks, B. Byrne, C. Camozzi, K. Cornetta, R. Crystal, Y. Fong, L. Gargiulo, R. Gopal‐srivastava, K. High, S. Jacobson, R. Jambou, Maureen Montgomery, E. Rosenthal, R. Samulski, S. Skarlatos, B. Sorrentino, James M. Wilson, Yun Xie, Jacqueline Corrigan‐Curay   +22 more
semanticscholar   +1 more source

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

Objective, comparative assessment of the penetration depth of temporal-focusing microscopy for imaging various organs [PDF]

, 2014
Temporal focusing is a technique for performing axially resolved widefield multiphoton microscopy with a large field of view. Despite significant advantages over conventional point-scanning multiphoton microscopy in terms of imaging speed, the need to ...
Bawendi, Moungi G, Bruns, Oliver Thomas, Rowlands, Christopher, So, Peter T. C.   +3 more
core   +1 more source

A U.S. Government-Coordinated Effort to Leverage Non-Human Primate Data to Facilitate Ebolavirus Vaccine Development

Vaccines, 2022
A United States Government (USG) interagency group, the Filovirus Animal Non-Clinical Group (FANG), has been established to support the development of biodefense medical countermeasures (MCMs).
Kimberly L. Taylor, Lynda Lanning, Lawrence Wolfraim, Sonia Shrivastava Gales, Colleen Sico, William E. Dowling, Lucy A. Ward, William C. Florence, Edwin Nuzum, Paula R. Bryant   +9 more
doaj   +1 more source

A coiled‐coil domain triggers oligomerization of MmpL10, the mycobacterial transporter of trehalose polyphleate precursor

FEBS Letters, EarlyView.
Most MmpLs transport lipids and glycolipids of the complex mycomembrane of mycobacteria. This study shows that MmpL10 from Mycobacterium smegmatis, the transporter of the trehalose polyphosphate precursor, harbors a coiled‐coil‐like extension. Biochemical and electron microscopy studies demonstrate that the coiled‐coil enables MmpL10 to trimerize.
Julie Couston, Jérôme Feuillard, Aurélie Ancelin, Joséphine Lai‐Kee‐Him, Konstantin Brodolin, Christian Chalut, Pontus Gourdon, Mickaël Blaise   +7 more
wiley   +1 more source

Augmentation of post-swelling surgical sealant potential of adhesive hydrogels [PDF]

, 2010
National Institutes of Health (U.S.) (Grant GM 49039)National Institutes of Health (U.S.) (Grant GM 1S10RR13886-01)Philip Morris InternationalDuPont (Firm)National Defense Science and Engineering Graduate ...
Anderson, Artzi, Artzi, Bader, Baker, Bhatia, Bhatia, Buchta, Burke, Ciapetti, Dalsin, Gade, Gawlak, Glaros, Hilborn, Hwang, Jackson, Kenneth Ward, Lee, Lee, Lin, Liu, Nugent, Pasternak, Peppas, Pretsch, Samuel, Sarvestani, Shazly, Shima, Sierra, Silver, Silverman, Statz, Suggs, Usha, Waite   +36 more
core   +1 more source

Solar UVR and Variations in Systemic Immune and Inflammation Markers

JID Innovations, 2021
The characterization of the effects of solar UVR on a broad set of circulating markers in systemic immunity and inflammation may provide insight into the mechanisms responsible for the UVR associations observed for several benign and malignant diseases ...
Zhi-Ming Mai, Scott N. Byrne, Mark P. Little, Michael R. Sargen, Elizabeth K. Cahoon   +4 more
doaj  

Climate Change, Human Health, and Biomedical Research: Analysis of the National Institutes of Health Research Portfolio

Environmental Health Perspectives, 2013
Background: According to a wide variety of analyses and projections, the potential effects of global climate change on human health are large and diverse. The U.S.
C. Jessup, J. Balbus, C. Christian, Ehsanul Haque, Sally Howe, Sheila A. Newton, B. Reid, L. Roberts, Erin E. Wilhelm, J. Rosenthal   +9 more
semanticscholar   +1 more source