Results 101 to 110 of about 999,131 (304)

Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography [PDF]

, 2009
We describe depth-resolved microscopy of cortical hemodynamics with high-speed spectral/Fourier domain optical coherence tomography (OCT). Stimulus-evoked changes in blood vessel diameter, flow, and total hemoglobin were measured in the rat somatosensory
Ances, Chen, David A. Boas, Devor, Faber, Fercher, Grinvald, Iwona Gorczynska, James G. Fujimoto, Kasai, Kleinfeld, Leitgeb, Maheswari, Ren, Sava Sakadžić, Srinivasan, Svetlana Ruvinskaya, Tso, Villringer, Vivek J. Srinivasan, Wang, Weicheng Wu   +21 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Detecting Disease in Radiographs with Intuitive Confidence

The Scientific World Journal, 2015
This paper argues in favor of a specific type of confidence for use in computer-aided diagnosis and disease classification, namely, sine/cosine values of angles represented by points on the unit circle. The paper shows how this confidence is motivated by
Stefan Jaeger
doaj   +1 more source

Topical Developments in High-Field Dynamic Nuclear Polarization [PDF]

, 2013
We report our recent efforts directed at improving high-field dynamic nuclear polarization (DNP) experiments. We investigated a series of thiourea nitroxide radicals and the associated DNP enhancements ranging from ε=25 to 82, which demonstrate the ...
Frantz, Derik K., Griffin, Robert Guy, Kiesewetter, Matthew K., Luchinat, Claudio, Michaelis, Vladimir K., Ong, Ta-Chung, Ravera, Enrico, Swager, Timothy M, Walish, Joseph John   +8 more
core   +1 more source

Liquid Hydroxyurea (Xromi) for Children With Sickle Cell Anemia: A New Solution Compounding Existing Problems

Pediatric Blood &Cancer, EarlyView.
Alexandra Power‐Hays, Charles T. Quinn
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Exploring Food, Agricultural, and Environmental Law and Policy Reforms

Journal of Agriculture, Food Systems, and Community Development, 2016
First paragraphs: Books have played an important role in shaping the United States' food, agricultural, and environmental systems. One of the most influential is a1906 book entitled The Jungle written by Upton Sinclair that used investigative reporting ...
Sheila Fleischhacker
doaj  

Absence of sex differences in serotonergic control of orbitofrontal cortex neuronal activity

Scientific Reports
The orbitofrontal cortex (OFC) is a brain region involved in cognitive processing, especially in tasks that require flexibility in decision-making. Serotonin (5-HT) plays a critical role in mediating OFC-dependent behavior, primarily through its actions ...
Kailin M. Mooney, Alexander F. Hoffman, Carl R. Lupica   +2 more
doaj   +1 more source

A Covering Method for Detecting Genetic Associations between Rare Variants and Common Phenotypes [PDF]

, 2010
Genome wide association (GWA) studies, which test for association between common genetic markers and a disease phenotype, have shown varying degrees of success.
A Helgadottir, B Li, BE Madsen, BF Cravatt, Christian von Mering, DE Reich, DP Jensen, DW Craig, E Emmanuelle Durand, Eric J. Topol, ES Lander, Gaurav Bhatia, GV Kryukov, H Li, JC Cohen, JC Cohen, JC Sipe, JC Sipe, JK Pritchard, JK Pritchard, Kelly Frazer, L Lovasz, M Maccarrone, M Maccarrone, M Yeager, MR Garey, Nicholas J. Schork, NJ Schork, NS Fearnhead, O Harismendy, Olivier Harismendy, R McPherson, S Engeli, S Nejentsev, TA Manolio, TD Müller, TM Frayling, TWTCC Consortium, V Di Marzo, V Di Marzo, V Di Marzo, Vikas Bansal, Vineet Bafna, W Bodmer, W Ji, W Lieb, YX Fu   +46 more
core   +5 more sources

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source