Results 101 to 110 of about 964,883 (379)

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Copper-Catalyzed Trifluoromethylation of Unactivated Olefins [PDF]

, 2011
Activating the inactive: A copper-catalyzed allylic trifluoromethylation of unactivated terminal olefins proceeds under mild conditions to produce linear allylic trifluoromethylated products with high E/Z selectivity (see scheme).
Allen, Ball, Beringer, Billard, Billard, Cantacuzène, Caserio, Cho, Chu, Davies, Dolbier, Duan, Eckenhoff, Eisenberger, Eisenberger, Fantasia, Grushin, Ignatowska, Iseki, Itoh, Kamigata, Kamigata, Kharasch, Kharasch, Kieltsch, Kieltsch, Kim, Knauber, Kobayashi, Koller, Koller, Konno, Liu, Lockhart, Ma, Miura, Müller, Nagib, Niedermann, Pooput, Prakash, Rawlinson, Senecal, Shibata, Shimizu, Stanek, Tomashenko, Umemoto, Umemoto, Umemoto, Wang, Welch, Yagupolskii, Yamazaki   +53 more
core   +1 more source

Diagnostic difficulties and possibilities of NF1-like syndromes in childhood

BMC Pediatrics, 2021
Background Neurofibromatosis type 1 (NF1), which is caused by heterozygous inactivating pathogenic variants in the NF1, has poor phenotypic expressivity in the early years of life and there are numerous conditions, including many other tumor ...
Eva Pinti, Krisztina Nemeth, Krisztina Staub, Anna Lengyel, Gyorgy Fekete, Iren Haltrich   +5 more
doaj   +1 more source

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Combining Path Integration and Remembered Landmarks When Navigating without Vision [PDF]

, 2013
This study investigated the interaction between remembered landmark and path integration strategies for estimating current location when walking in an environment without vision.
AM Brouwer, Amy A. Kalia, AR Lew, AS Etienne, BJ Stankiewicz, CG Ellard, D Andel, D Kersten, EC Tolman, Gordon E. Legge, J Loomis, JA Thomson, JJ Rieser, JM Loomis, JM Loomis, JW Philbeck, K Cheng, KP Körding, L Tcheang, M Collett, M Nardini, MA Amorim, Marc O. Ernst, MO Ernst, MR Tarampi, MS Landy, NV Odell, P Foo, Paul R. Schrater, RJ van Beers, SS Chance, SS Fukusima, WR Miles   +32 more
core   +3 more sources

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Quantitative Susceptibility Mapping by Inversion of a Perturbation Field Model: Correlation With Brain Iron in Normal Aging [PDF]

, 2014
There is increasing evidence that iron deposition occurs in specific regions of the brain in normal aging and neurodegenerative disorders such as Parkinson's, Huntington's, and Alzheimer's disease.
Adalsteinsson, Elfar, Jenkinson, Mark, Pfefferbaum, Adolf, Poynton, Clare B., Sullivan, Edith V., Wells, William M.   +5 more
core   +1 more source

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source

Effect of Intravitreous Anti–Vascular Endothelial Growth Factor Therapy on Choroidal Thickness in Neovascular Age-Related Macular Degeneration Using Spectral-Domain Optical Coherence Tomography [PDF]

, 2013
A critical method of monitoring patients with neovascular age-related macular degeneration (AMD) being treated with anti–vascular endothelial growth factor (anti-VEGF) is optical coherence tomography (OCT), which uses low-coherence interferometry of ...
Adhi, Mehreen, Branchini, Lauren, Duker, Jay S., Flores-Moreno, Ignacio, Fujimoto, James G., Manjunath, Varsha, Regatieri, Caio   +6 more
core   +1 more source

Detecting Disease in Radiographs with Intuitive Confidence

The Scientific World Journal, 2015
This paper argues in favor of a specific type of confidence for use in computer-aided diagnosis and disease classification, namely, sine/cosine values of angles represented by points on the unit circle. The paper shows how this confidence is motivated by
Stefan Jaeger
doaj   +1 more source