Results 111 to 120 of about 999,131 (304)

Integrative Gene Set Analysis: Application to Platinum Pharmacogenomics [PDF]

, 2014
Integrative genomics has the potential to uncover relevant loci, as clinical outcome and response to chemotherapies are most likely not due to a single gene (or data type) but rather a complex relationship involving genetic variation, mRNA, DNA ...
Abo, Ryan, Batzler, Anthony, Biernacka, Joanna M., Fridley, Brooke L., Jenkins, Gregory D., Moyer, Ann M., Tan, Xiang-Lin, Wang, Liewei   +7 more
core   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

FEDERAL SUPPORT OF SCIENTIFIC INQUIRY IN THE UNITED STATES: CURRENT EVOLUTION UNDER THE POLITICAL STRUGGLE

Сравнительная политика, 2016
2000’s and 2010’s witnessed diminishing margin of the United States in science and technology. Meanwhile, the U.S. remains a clear leader in this fi eld. Major driving force of the country’s success in the second half of the ХХ century remained assertive
I. A. Istomin
doaj   +1 more source

Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism [PDF]

, 2013
Metformin inhibits cancer cell proliferation, and epidemiology studies suggest an association with increased survival in patients with cancer taking metformin; however, the mechanism by which metformin improves cancer outcomes remains controversial.
Bell, Eric L., Bellinger, Gary, Blenis, John, Blouin, Marie Jose, Cantley, Lewis C., Csibi, Alfred, Davidson, Shawn Michael, Fendt, Sarah-Maria, Fiske, Brian Prescott, Guarente, Leonard Pershing, Keibler, Mark Andrew, Mayers, Jared R., Olumi, Aria F., Patnaik, Akash, Pollak, Michael N., Schwab, Matthias, Stephanopoulos, Gregory, Vander Heiden, Matthew G., Wirth, Gregory J.   +18 more
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Next-generation sequencing to monitor the spread of antimicrobial resistance

Genome Medicine, 2017
Next-generation sequencing is increasingly being used to monitor current and historic events related to the emergence and spread of antimicrobial resistance.
Michael Otto
doaj   +1 more source

Expansion microscopy of zebrafish for neuroscience and developmental biology studies [PDF]

, 2018
Expansion microscopy (ExM) allows scalable imaging of preserved 3D biological specimens with nanoscale resolution on fast diffraction-limited microscopes.
Asano, Shoh M, Baier, Herwig, Boyden, Edward, Celiker, Orhan Tunc, Chen, Linlin, Costa, Emma K., Dick, Cortni D., Engert, Florian, Freifeld, Limor, Förster, Dominique, Gagnon, James A., Gao, Ruixuan, Martin Alarcon, Daniel Alberto, Odstrcil, Iris, Ramirez, Alyson, Randlett, Owen, Reginato, Paul Louis, Schoppik, David   +17 more
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Direct Observation of Multiple Tautomers of Oxythiamine and their Recognition by the Thiamine Pyrophosphate Riboswitch [PDF]

, 2013
Structural diversification of canonical nucleic acid bases and nucleotide analogues by tautomerism has been proposed to be a powerful on/off switching mechanism allowing regulation of many biological processes mediated by RNA enzymes and aptamers ...
Essigmann, John M., Li, Deyu, Mitra, Koyel, Peng, Chunte Sam, Silvestre, Katherine J., Singh, Vipender, Tokmakoff, Andrei   +6 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source