Results 141 to 150 of about 964,883 (379)

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Noninvasive optical inhibition with a red-shifted microbial rhodopsin [PDF]

, 2014
Optogenetic inhibition of the electrical activity of neurons enables the causal assessment of their contributions to brain functions. Red light penetrates deeper into tissue than other visible wavelengths. We present a red-shifted cruxhalorhodopsin, Jaws,
A Berényi, A Hofherr, A Nimmerjahn, A Roggan, AB Arrenberg, Amy S Chuong, AN Bashkatov, AN Yaroslavsky, Andreas T Sørensen, Andrew Young, BN Armbruster, Botond Roska, Brian D Allen, Brian Y Chow, BY Chow, CA Giller, CH Sung, Craig R Forest, D Huber, D Ma, DB Farber, Edward S Boyden, EJ Yoder, ES Boyden, F Naarendorp, GH Jacobs, Gillian A C Matthews, H Ye, HT Xu, I Ibañez-Tallon, J Grutzendler, J Hatazawa, J Mattis, J Menzler, J Otomo, J Tønnesen, JA Cardin, JA Cardin, JC Grieger, Jessica A Cardin, JT Trachtenberg, JV Raimondo, JY Lin, Kay M Tye, KM Tye, L Madisen, L Wang, Leah C Acker, M Jazayeri, M Rüdiger, Masaaki Ogawa, Mike A Henninger, Mitra L Miri, N Ugryumova, NA Scott, Nathan C Klapoetke, NC Klapoetke, NR Hackett, O Yizhar, P Anikeeva, P Kreiss, P Znamenskiy, PJ Drew, R Hira, Rachel C Bandler, RH Kramer, S Hippenmeyer, S Ohayon, S-H Lee, SB Kodandaramaiah, Shreshtha B Ramanlal, SI Al-Juboori, Suhasa B Kodandaramaiah, T Binzoni, T Tsubota, T Tsunematsu, V Busskamp, V Busskamp, V Gradinaru, V Gradinaru, Volker Busskamp, VS Polikov, X Han, X Han, X Li, Xue Han, Yingxi Lin   +86 more
core   +1 more source

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Waking up dormant tumors [PDF]

, 2011
As appreciation grows for the contribution of the tumor microenvironment to the progression of cancer, new evidence accumulates to support that the participation of stromal cells can extend beyond the local environment.
CH Ong, J Wels, JA Joyce, JC Ho, Joyce C Tse, Raghu Kalluri, SS McAllister, SS McAllister   +7 more
core   +2 more sources

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source

Redox, haem and CO in enzymatic catalysis and regulation [PDF]

, 2012
The present paper describes general principles of redox catalysis and redox regulation in two diverse systems. The first is microbial metabolism of CO by the Wood–Ljungdahl pathway, which involves the conversion of CO or H2/CO2 into acetyl-CoA, which ...
Bender, Güneş, Bianchetti, Christopher M., Britt, R. David, Cramer, Stephen P., Doukov, Tzanko I., Drennan, Catherine L., George, Simon J., Gupta, Nirupama, Jakob, Ursula, Jenkins, Paul M., Kung, Yan, Leichert, Lars, Martens, Jeffrey R., Phillips, George N., Ragsdale, Stephen W., Stich, Troy A., Yan, Lifen, Yi, Li   +17 more
core   +1 more source

Exhausted and Senescent T Cells at the Maternal-Fetal Interface in Preterm and Term Labor

Journal of Immunology Research, 2019
Successful pregnancy requires a tightly-regulated equilibrium of immune cell interactions at the maternal-fetal interface (i.e., the decidual tissues), which plays a central role in the inflammatory process of labor.
Rebecca Slutsky, Roberto Romero, Yi Xu, Jose Galaz, Derek Miller, Bogdan Done, Adi L. Tarca, Sabrina Gregor, Sonia S. Hassan, Yaozhu Leng, Nardhy Gomez-Lopez   +10 more
doaj   +1 more source

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner [PDF]

, 2011
The blood vessels of cancerous tumours are leaky and poorly organized. This can increase the interstitial fluid pressure inside tumours and reduce blood supply to them, which impairs drug delivery. Anti-angiogenic therapies—which ‘normalize’ the abnormal
AG Sorensen, C Pozrikidis, CG Willett, D Peer, Dai Fukumura, E Ruoslahti, F Winkler, F Yuan, H Hashizume, H Sarin, JA Nagy, JA Nagy, John D. Martin, JW Baish, JW Baish, Moungi G. Bawendi, Ou Chen, P Carmeliet, PM Bungay, Rakesh K. Jain, RK Jain, RK Jain, RK Jain, RT Tong, S Goel, SK Hobbs, T Nakahara, Triantafyllos Stylianopoulos, TT Batchelor, Vikash P. Chauhan, VP Chauhan, VP Chauhan, Walid S. Kamoun, WM Deen, Y Gazit, Y Gazit, Y Matsumura, Z Popovic, Zoran Popović   +38 more
core   +1 more source