Results 161 to 170 of about 964,883 (379)

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Reevaluation of Historical Exposures to Ethylene Oxide Among U.S. Sterilization Workers in the National Institute of Occupational Safety and Health (NIOSH) Study Cohort [PDF]

, 2019
Kenneth T. Bogen, Patrick J. Sheehan, Ciriaco Valdez‐Flores, Abby A. Li   +3 more
openalex   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Speech Communication [PDF]

Contains reports on five research projects.C.J. Lebel FellowshipNational Institutes of Health (Grant 5 T32 NSO7040)National Institutes of Health (Grant 5 R01 NS04332)National Institutes of Health (Grant 5 R01 NS21183)National Institutes of Health (Grant ...
Abramson, Katie, Allen, Jonathan, Alwan, Abeer A., Anderson, M., Bateman, Nicholas P. T., Bickley, Corine A., Blush, M., Boyce, Suzanne E., Chapin Ringo, Carol, Chasaide, A. ni, Cohen, M., Daly, Nancy, Dubois, S., Espy-Wilson, Carol Y., Forestell, Ann F., Glass, James R., Glicksman, Laura B., Goldhor, R., Gosy, M., Halle, Morris, Hillman, Robert E., Hirahara, T., Hirose, K., Holmberg, Eva B., Hopkins, G., Howitt, Andrew William, Huang, Caroline B., Isaacs, Katy, Jankowski, Charles, Kassel, Rob, Kaufman, D. H., Kawasaki, Haruko, Key, K. K., Keyser, Samuel J., Klatt, Dennis H., Kline, K., Lamel, Lori, Landry, Joseph, Lane, Harlan L., Larkey, Leah S., Lauritzen, N., Leung, Hong, Lim, A., Locke, John L., Makhoul, J. I., Manuel, Sharon Y., Marcus, J. N., McCandless, Michael K., Mitra, H., North, Keith, Pao, Christine, Pastel, L., Perkell, Joseph S., Phillips, M., Pitrelli, John, Randolph, Mark A., Seneff, Stephanie, Shattuck-Hufnagel, Stephanie, Shaw, A., Stevens, Kenneth N., Suzuki, Noriko, Tierney, S., Volaitis, L., Webster, Jane W., Wheeler, L., Whitney, Dave, Wilson, T., Wint, Arlene E., Wong, Albert K., Wong, D., Yoshida, K., Zue, Victor W.   +71 more
core  

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

The staphylococcal exopolysaccharide PIA – Biosynthesis and role in biofilm formation, colonization, and infection

Computational and Structural Biotechnology Journal, 2020
Exopolysaccharide is a key part of the extracellular matrix that contributes to important mechanisms of bacterial pathogenicity, most notably biofilm formation and immune evasion. In the human pathogens Staphylococcus aureus and S.
Hoai T.T. Nguyen, Thuan H. Nguyen, Michael Otto   +2 more
doaj  

An Evaluation of the Fungistatic Activity of Serum121From the Division of Dermatology, Department of Medicine and Department of Bacteriology, University of Miami School of Medicine, Miami and Coral Gables, Florida.2This work was supported in part by a grant from the National Institutes of Health, P.H.S. No. E-1546, and in part by U.S. Army Contract #DA-49-007-MD-731.

, 1959
Frank J. Roth, Carolyn C. Boyd, Seichiro Sagami, Harvey Blank   +3 more
openalex   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Evaluation of Arginase Activity in Normal Epidermal Tissue and Pathological Stratum Corneum11From the Dermatology Service, General Medicine Branch, National Cancer Institute, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Maryland.

, 1958
Simon Rothberg, Eugene J. Van Scott, S.L. Newberry   +2 more
openalex   +1 more source