Results 231 to 240 of about 999,131 (304)

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Mental health service experiences regarding sexual orientation: Relations with demographics, depression, and suicidality among queer adults. [PDF]

Psychol Serv
Hall WJ, Williams DY, Xu Y, Scott M, Chiang PC, Englert AR, Leite JA, Dawes HC, Richardson SC, Srivastava A.   +9 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Comparison of pre- and post-natal environmental exposures in United States versus Brazilian patients with juvenile dermatomyositis. [PDF]

Clin Exp Rheumatol
Arabi TMA, Farhat SCL, Valoes CC, Shenoi S, Kim S, Carneiro BOL, Rider LG, Elias AM.   +7 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Midlife and late-life population attributable fractions of risk factors for dementia in the United States: The Dementia Risk Prediction Project. [PDF]

Alzheimers Dement
Li JM, Gauen AM, Zmora R, Stephen JJ, Petito LC, Scholtens D, Peterson EA, Kohli-Lynch C, Mansolf M, Sedaghat S, Giorgio K, Gross AL, Helmer C, Debette S, Soumaré A, Ikram MA, Wolters FJ, Seshadri S, Satizabal CL, Himali J, Levine DA, Briceño EM, Sorond FA, Launer LJ, Li D, Mbangdadji D, Zhao L, Lloyd-Jones DM, Lopez OL, Judd SE, Hughes TM, Gudnason V, Aiello AE, Fohner A, Singh-Manoux A, Allen NB.   +35 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Rural-Urban Patterns in Household Rules Limiting Combustible Tobacco, Noncombustible Tobacco, and E-Cigarette Use. [PDF]

Ann Am Thorac Soc
Steinberg AW, Ozga JE, Tang Z, Stanton CA, Sargent JD, Paulin LM.   +5 more
europepmc   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Setting the Table: Determining Which Options Clinicians Should Disclose to Patients. [PDF]

J Gen Intern Med
Dickert NW, Wendler D.
europepmc   +1 more source