Results 71 to 80 of about 964,883 (379)

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

Enhancing Protease Activity Assay in Droplet-Based Microfluidics Using a Biomolecule Concentrator [PDF]

, 2011
We introduce an integrated microfluidic device consisting of a biomolecule concentrator and a microdroplet generator, which enhances the limited sensitivity of low-abundance enzyme assays by concentrating biomolecules before encapsulating them into ...
Abate A. R., Agresti J. J., Aniruddh Sarkar, Blum G., Breadmore M. C., Brouzes E., Chen D. L., Chia-Hung Chen, Derda R., Dittrich P. S., Douglas A. Lauffenburger, Edgar J. S., Holtze C., Huebner A., Huebner A., Hughes A. J., J. N., Jambovane S., Joensson H. N., Jongyoon Han, Kim P., Kim S. J., Kim S. J., Kim S. J., Kleiner D., Koster S., Kreutz J. E., Lee J. H., Lee J. H., Lee J. H., Li L., Li L., Li L., Li L., Linda G. Griffith, Miles A. Miller, Miller M. A., Oliver G., Probstein R. F., Song H., Sung Jae Kim, Theberge A. B., Theberge A. B., Vincent M. E., Wang Y. C., Wang Y.-C., Wild D., Wolf K., Yong-Ak Song, Z. Y.   +49 more
core   +1 more source

Selective Activation of Cholinergic Interneurons Enhances Accumbal Phasic Dopamine Release: Setting the Tone for Reward Processing

Cell Reports, 2012
Dopamine plays a critical role in motor control, addiction, and reward-seeking behaviors, and its release dynamics have traditionally been linked to changes in midbrain dopamine neuron activity.
Roger Cachope, Yolanda Mateo, Brian N. Mathur, James Irving, Hui-Ling Wang, Marisela Morales, David M. Lovinger, Joseph F. Cheer   +7 more
doaj   +1 more source

Approaches by the US National Institutes of Health to support rigorous scientific research on dietary supplements and natural products.

Drug Testing and Analysis, 2016
Mechanistic, clinical, and epidemiological research relevant to dietary supplements (DS) is supported by the U.S. National Institutes of Health. The Office of Dietary Supplements and the National Center for Complementary and Integrative Health promote ...
A. Kuszak, D. C. Hopp, J. Williamson, J. Betz, B. Sorkin   +4 more
semanticscholar   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

NIH guidelines for research involving recombinant DNA molecules (NIH guidelines) [PDF]

, 2002
132 pages.Defines the official National Institutes of Health guidelines for conducting research involving "recombinant DNA molecules", which includes the development of genetically-modified organisms such as transgenic animals and ...
National Institutes of Health (U.S.)
core  

Structure–function–property–design interplay in biopolymers: Spider silk [PDF]

, 2018
Spider silks have been a focus of research for almost two decades due to their outstanding mechanical and biophysical properties. Recent advances in genetic engineering have led to the synthesis of recombinant spider silks, thus helping to unravel a ...
Buehler, Markus J, Jacobsen, Matthew, Kaplan, David L., Tokareva, Olena, Wong, Joyce   +4 more
core   +1 more source

On the failure of scientific research: an analysis of SBIR projects funded by the U.S. National Institutes of Health [PDF]

Scientometrics, 2017
The Small Business Innovation Research (SBIR) program is the primary source of public funding in the United States for research by small firms on new technologies, and the National Institutes of Health (NIH) is a major contributor to that funding agenda. Although previous research has explored the determinants of research success for NIH SBIR projects,
Jeremy W. Bray, Albert N. Link, Martin Andersen   +2 more
openaire   +2 more sources

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Prostate Cancer Incidence Rates in Africa

Prostate Cancer, 2011
African American men have among the highest prostate cancer incidence rates in the world yet rates among their African counterparts are unclear. In this paper, we compared reported rates among black men of Sub-Saharan African descent using data from the ...
Lisa W. Chu, Jamie Ritchey, Susan S. Devesa, Sabah M. Quraishi, Hongmei Zhang, Ann W. Hsing   +5 more
doaj   +1 more source