Results 81 to 90 of about 964,883 (379)

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

Iron(II)-Catalyzed Trifluoromethylation of Potassium Vinyltrifluoroborates [PDF]

, 2011
Exchanging BF[subscript 3] by CF[subscript 3]: The title reaction proceeds under exceedingly mild reaction conditions and provides 2-arylvinyl- and 2-heteroarylvinyl-substituted substrates with E/Z selectivities of more than 95:5.
Allen, Cho, Cho, Chu, Chu, Eisenberger, Eisenberger, Fantasia, Furukawa, Hiyama, Ji, Kawai, Koller, Koller, Liu, Ma, Maimone, Matsnev, Muller, Nagib, Nagib, Noritake, Oishi, Parsons, Prakash, Senecal, Stanek, Tomashenko, Wang, Watson, Xu, Xu, Yamazaki, Ye, Zhang, Zhang   +35 more
core   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

A FreeSurfer-compliant consistent manual segmentation of infant brains spanning the 0-2 year age range [PDF]

, 2014
We present a detailed description of a set of FreeSurfer compatible segmentation guidelines tailored to infant MRI scans, and a unique data set of manually segmented acquisitions, with subjects nearly evenly distributed between 0 and 2 years of age.
Ben-Avi, Emma, Choe, Myong-sun, de Macedo Rodrigues, Katyucia, Drottar, Marie, Fischl, Bruce, Grant, P. Ellen, Sliva, Danielle D., Wang, Ruopeng, Zollei, Lilla   +8 more
core   +2 more sources

Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Systematic Review for a National Institutes of Health Pathways to Prevention Workshop

Annals of Internal Medicine, 2015
Myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) is a debilitating multisystem condition characterized by chronic and disabling fatigue and several other symptoms, including pain, sleep disturbance, neurologic and cognitive changes, motor ...
M.E. Beth Smith, E. Haney, M. McDonagh, M. Pappas, M. Daeges, Ngoc Wasson, R. Fu, H. Nelson   +7 more
semanticscholar   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Molecular Biomechanics: The Molecular Basis of How Forces Regulate Cellular Function [PDF]

, 2010
Recent advances have led to the emergence of molecular biomechanics as an essential element of modern biology. These efforts focus on theoretical and experimental studies of the mechanics of proteins and nucleic acids, and the understanding of the ...
A Aksimentiev, A Parekh, AF Oberhauser, AG Tzakos, AJ Engler, AJ Hudspeth, Alan J. Grodzinsky, AS Khalil, B Huang, B Martin, BD Brower-Toland, BJ Pfister, BW Bisgrove, C Hoffmann, C Yuan, C Zhu, C Zhu, CA Siedlecki, Cheng Zhu, CJ World, CP Johnson, D Choquet, D Mertz, D Spetzler, Daniel A. Fletcher, DE Ingber, DH Dean, DJ Tschumperlin, E Evans, E Evans, EA Jares-Erijman, EL Florin, EM Puchner, F Allen, F Kong, F Meng, FH Silver, G Bao, G Bao, G Bao, Gang Bao, GD Nayak, GI Bell, H Hess, HL Howie, HM O’Hare, J Chen, J Gullingsrud, J Howard, JC Effler, JH Lee, JM Williams, JZ Lou, K Autumn, K Ghosh, K Konstantopoulos, KCL Neuman, KI Willig, KS Kolahi, L Deng, LG Ng, M Bathe, M Dembo, M Gao, M Gautam, M Rief, M Sundberg, MD Basson, MGL Heuvel van den, MH Zaman, ML Smith, Mohammad R. K. Mofrad, MR Mofrad, NR Alexander, P Santangelo, PA Sims, PC Harris, PE Marszalek, PF Davies, RD Kamm, RD Vale, Roger D. Kamm, RR Brau, S Furuike, S Lehoux, S Usami, S Yefimov, SE Lee, SE Lee, SM Block, SS Suri, T Fischer, T Suchyna, T Yago, TJ Park, TR Strick, V Vogel, V Vogel, VP Hytonen, W Huang, W Hwang, WE Thomas, Wendy Thomas, Wonmuk Hwang   +103 more
core   +1 more source

Combined thrombogenic effects of vessel injury, pregnancy and procoagulant immune globulin administration in mice

Thrombosis Journal, 2020
Background Pregnant women are at increased risk of thrombotic adverse events. Plasma derived immune globulin (IG) products, which are used in pregnancy for various indications, may contain procoagulant impurity activated coagulation factor XI (FXIa ...
Yanqun Xu, Yideng Liang, Leonid Parunov, Daryl Despres, Michael Eckhaus, Dorothy Scott, Mikhail Ovanesov, Evi B. Struble   +7 more
doaj   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

A generative approach for image-based modeling of tumor growth [PDF]

, 2011
22nd International Conference, IPMI 2011, Kloster Irsee, Germany, July 3-8, 2011. ProceedingsExtensive imaging is routinely used in brain tumor patients to monitor the state of the disease and to evaluate therapeutic options.
A. Gooya, A. Hamamci, A. Klimke, A. Mohamed, B.B. Cuadra, B.H. Menze, C. Hogea, D. Cobzas, E. Konukoglu, E.C. Alvord, E.I. Zacharaki, G.B. Caseiras, H. Haario, H.-J. Bungartz, J. Pallud, J.J. Corso, K.R. Swanson, M. Prastawa, M.A.J. Chaplain, N. Zarabas, O. Clatz, O. Ganslandt, P. McCorquodale, S. Hirsch, S.K. Kyriacou   +24 more
core   +5 more sources