Results 91 to 100 of about 8,314,274 (416)
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin+14 more
wiley +1 more source
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi+5 more
wiley +1 more source
Promoting a Rapid Deployment of New Services for Remote Reference at a National Laboratory [PDF]
Libraries around the world use Springshare library products to expand their reference and information literacy services. The scholarly literature primarily addresses the use of Springshare’s LibGuides and LibChat in academic libraries.
Moyer, Elizabeth +2 more
doaj
Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas+15 more
wiley +1 more source
Representing Contextualized Information in the NSDL [PDF]
The NSDL (National Science Digital Library) is funded by the National Science Foundation to advance science and match education. The inital product was a metadata-based digital library providing search and access to distributed resources. Our recent work recognizes the importance of context - relations, metadata, annotations - for the pedagogical value
arxiv
Differential distribution of red cell membrane glycoproteins [PDF]
In vitro study of the distribution of membrane glycoproteins during human red cell aging revealed a major band on SDS-polyacrylamide gel incubated at physiological temperature in normal saline or Krebs-Ringer solution without calcium but not with calcium.
Suhail, M.
core
Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song+13 more
wiley +1 more source
Sequence Read Archive submissions to the National Center for Biotechnology Information often lack useful metadata, which limits the utility of these submissions.
Kenneth S. Katz+5 more
doaj +1 more source
Bibliography and photographs of a display of government documents from the Armed Forces Staff College Library, Virginia.https://cornerstone.lib.mnsu.edu/lib-services-govdoc-display-library/1000/thumbnail ...
Armed Forces Staff College Library
core +1 more source