Results 291 to 300 of about 6,058,834 (370)

Malignant Hepatoblast‐Like Cells Sustain Stemness via IGF2‐Dependent Cholesterol Accumulation in Hepatoblastoma

Advanced Science, EarlyView.
Hepatoblastoma, an aggressive childhood liver tumor, origins from malignant hepatoblast‐like cells. Single‐cell analysis reveals IGF2‐driven pathways promoting malignancy. Targeting these pathways offers promising treatments, with serum IGF2 as a potential diagnostic biomarker.
Miao Ding, Siwei Mao, Han Wu, Sijia Fang, Ni Zhen, Tianshu Chen, Jiabei Zhu, Xiaochen Tang, Xiaoyang Wang, Fenyong Sun, Guoqing Zhu, Qiuhui Pan, Ji Ma   +12 more
wiley   +1 more source

Bioprinted Patient‐Derived Organoid Arrays Capture Intrinsic and Extrinsic Tumor Features for Advanced Personalized Medicine

Advanced Science, EarlyView.
An embedded bioprinting enabled‐arrayed patient‐derived organoids (Eba‐PDO) platform that replicates intrinsic and extrinsic tumor characteristics is introduced. Eba‐PDOs more accurately mimic tissue than standard PDOs (Std‐PDOs) due to maturation in the tumor microenvironment.
Jonghyeuk Han, Hye‐Jin Jeong, Jeonghan Choi, Hyeonseo Kim, Taejoon Kwon, Kyungjae Myung, Kyemyung Park, Jung In Park, Samuel Sánchez, Deok‐Beom Jung, Chang Sik Yu, In Ho Song, Jin‐Hyung Shim, Seung‐Jae Myung, Hyun‐Wook Kang, Tae‐Eun Park   +15 more
wiley   +1 more source

Developing Quorum Sensing‐Based Collaborative Dynamic Control System in Halomonas TD01

Advanced Science, EarlyView.
A standardized and streamlined inducer‐free quorum sensing (QS)‐based collaborative dynamic control pattern is developed for sufficient gene expression control in Halomonas TD by mixing two engineered cells, cells A and B. Proof‐of‐concept studies are designed to test the dynamic control performance in mixed cultures in fed‐batch conditions.
Yi‐Na Lin, Yu‐Xi Li, Ye Zheng, Yi‐Hao Deng, Kai‐Xuan Liu, Yue Gan, Hao Li, Jun Wang, Jia‐Wen Peng, Rui‐Zhe Deng, Huai‐Ming Wang, Hui Wang, Jian‐Wen Ye   +12 more
wiley   +1 more source

GRP78 Nanobody‐Directed Immunotoxin Activates Innate Immunity Through STING Pathway to Synergize Tumor Immunotherapy

Advanced Science, EarlyView.
A GRP78 nanobody‐directed immunotoxin suppresses cancer progression and metastasis by enhancing antitumor immunity via STING pathway activation, offering a pan‐cancer‐targeted approach and immunotherapy combination strategy. Abstract The lack of targetable antigens poses a significant challenge in developing effective cancer‐targeted therapies.
Huifang Wang, Runhua Zhou, Chengchao Xu, Lingyun Dai, Rui Hou, Liuhai Zheng, Chunjin Fu, Guangwei Shi, Jingwei Wang, Yang Li, Jinpeng Cen, Xiaolong Xu, Le Yu, Yilei Li, Jigang Wang, Qingfeng Du, Zhijie Li   +16 more
wiley   +1 more source

XANES reference library of sulphur-containing compounds for biological research: a status report from the ASTRA beamline at the SOLARIS National Synchrotron Radiation Centre. [PDF]

RSC Adv
Klonecka A, Sławek J, Gazdowicz G, Maximenko A, Sławek A, Piszak M, Lichtenberg H, Kozak M.   +7 more
europepmc   +1 more source

National Emergency Library

, 2020
openaire   +1 more source

Rapid assay development for low input targeted proteomics using a versatile linear ion trap. [PDF]

Nat Commun
Shannon AE, Teodorescu RN, Song NJ, Heil LR, Jacob CC, Remes PM, Li Z, Rubinstein MP, Searle BC.   +8 more
europepmc   +1 more source

A genome-wide screen identifies genes required for erythroid differentiation. [PDF]

Nat Commun
Myers G, Friedman A, Yu L, Pourmandi N, Kerpet C, Ito MA, Saba R, Tang V, Ozel AB, Bergin IL, Johnson CN, Ku CJ, Wang Y, Balbin-Cuesta G, Lim KC, Lin Z, Drysdale C, McGee B, Kurita R, Nakamura Y, Liu X, Siemieniak D, Singh SA, Lyssiotis CA, Maillard I, Weisman LS, Engel JD, Khoriaty R.   +27 more
europepmc   +1 more source

Infective Endocarditis Caused by <i>Abiotrophia defectiva</i>: A Unique Case Complicated by Mitral Valve Perforation. [PDF]

Clin Case Rep
Ababneh R, Rhabneh L, Qaddour S, Algorani E, Aloqaily M, Abool Maaly CA.   +5 more
europepmc   +1 more source