Results 61 to 70 of about 6,074,244 (344)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Setting up a National Research Data Curation Service for Qatar: Challenges and Opportunities

open access: yesInternational Journal of Digital Curation, 2018
Over the past decade, Qatar has been making considerable progress towards developing a sustainable research culture for the nation. The main driver behind Qatar’s progress in research and innovation is Qatar Foundation for Education, Science, and ...
Arif Shaon   +2 more
doaj   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

Building an Aotearoa New Zealand-wide Digital Curation Community of Practice

open access: yesInternational Journal of Digital Curation, 2020
How do you build awareness and capability for digital curation knowledge and experience across a country? The National Library of New Zealand has a statutory role in supporting and advancing the work of Aotearoa New Zealand libraries to ensure ...
Jessica Moran   +2 more
doaj   +1 more source

STAT: a fast, scalable, MinHash-based k-mer tool to assess Sequence Read Archive next-generation sequence submissions

open access: yesGenome Biology, 2021
Sequence Read Archive submissions to the National Center for Biotechnology Information often lack useful metadata, which limits the utility of these submissions.
Kenneth S. Katz   +5 more
doaj   +1 more source

The Formation of a National Musical Library [PDF]

open access: yesProceedings of the Musical Association, 1877
The title of my paper, ‘The Formation of a National Musical Library,’ may be open to some misconception, and I should like therefore to premise that it does not simply mean a library of national music, though that certainly should form a very important and indispensable section of any national library.
openaire   +3 more sources

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

open access: yesMolecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson   +11 more
wiley   +1 more source

Library marketing, the National Electronic Library, library pedagogy

open access: yesБиблиосфера, 2015
Stages of marketing development in general and library marketing in particular are considered. Prospects of library marketing development in Russia depend on the National Electronic Library project and the concept 3.0 of marketing.
A. V. Sokolov
doaj  

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