Results 41 to 50 of about 584,455 (290)

Outcomes after angiography with sodium bicarbonate and acetylcysteine [PDF]

, 2018
Background: Intravenous sodium bicarbonate and oral acetylcysteine are widely used to prevent acute kidney injury and associated adverse outcomes after angiography without definitive evidence of their efficacy.
,, Androsenko, Maria, Bhatt, Deepak L., Brophy, Mary, Cass, Alan, Chertow, Glenn M., Conner, Todd A., Ferguson, Ryan, Gallagher, Martin, Garcia, Santiago, Jneid, Hani, Kaufman, James, McFalls, Edward O., Myles, John, Palevsky, Paul M., Parikh, Chirag R., Shunk, Kendrick, Thwin, Soe-Soe, Weisbord, Steven D., Wu, Hongsheng   +19 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Holistic Health, Disadvantage, Higher Education Access and Success: A Reflection

Journal of Student Affairs in Africa, 2019
The objective of this article is to reflect upon the relationships amongst health, disadvantage, educational opportunities, and higher education access and success.
Angela A. Morris-Paxton, Johanna M. van Lingen, Diane Elkonin   +2 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Los CaCCs: proteínas multifuncionales, de la fisiología a la enfermedad

Ciencia Ergo Sum, 2019
Los CaCCs son proteínas formadoras de poros que se ubican en la membrana celular. Los CaCCs permiten el paso de iones a través de la membrana, lo cual es clave para una adecuada realización de funciones celulares y para el desarrollo de algunas ...
Juan A. Contreras-Vite, José Luis Tellez-Arreola, Jerónimo Mondragón Suarez   +2 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

SAFETY OF HOSPITALIZED ELDERLY PATIENTS: AN INTEGRATIVE LITERATURE REVIEW

Cogitare Enfermagem, 2016
The objective was to identify how the safety of hospitalized elderly patients has been discussed in the scientific literature. An integrative literature review was undertaken in the databases Literatura Latino Americana e do
Thayane Dias dos Santos, Fátima Helena do Espírito Santo, Karinne Cristinne da Silva Cunha, Carla Lube de Pinho Chibante   +3 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Health Literacy: An overview of an emerging field [PDF]

, 2011
According to the National Adult Literacy Survey, nearly 90 million American adults test below a high school level for literacy skills (Kirsch, Jungeblut, Jenkins & Kolstad, 1993).Because most health materials are written at least at the high school level,
Flaherty, Mary Grace
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source