Results 51 to 60 of about 3,273,344 (325)

Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample

Genome Biology, 2022
Background Accurate detection of somatic mutations is challenging but critical in understanding cancer formation, progression, and treatment. We recently proposed NeuSomatic, the first deep convolutional neural network-based somatic mutation detection ...
Sayed Mohammad Ebrahim Sahraeian, Li Tai Fang, Konstantinos Karagiannis, Malcolm Moos, Sean Smith, Luis Santana-Quintero, Chunlin Xiao, Michael Colgan, Huixiao Hong, Marghoob Mohiyuddin, Wenming Xiao   +10 more
doaj   +1 more source

Impact of peer review on discussion of study limitations and strength of claims in randomized trial reports: a before and after study

Research Integrity and Peer Review, 2019
Background In their research reports, scientists are expected to discuss limitations that their studies have. Previous research showed that often, such discussion is absent. Also, many journals emphasize the importance of avoiding overstatement of claims.
Kerem Keserlioglu, Halil Kilicoglu, Gerben ter Riet   +2 more
doaj   +1 more source

An Automated Method to Enrich Consumer Health Vocabularies Using GloVe Word Embeddings and An Auxiliary Lexical Resource [PDF]

, 2021
Background: Clear language makes communication easier between any two parties. A layman may have difficulty communicating with a professional due to not understanding the specialized terms common to the domain. In healthcare, it is rare to find a layman knowledgeable in medical terminology which can lead to poor understanding of their condition and/or ...
arxiv   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

TREC-COVID: Constructing a Pandemic Information Retrieval Test Collection [PDF]

arXiv, 2020
TREC-COVID is a community evaluation designed to build a test collection that captures the information needs of biomedical researchers using the scientific literature during a pandemic. One of the key characteristics of pandemic search is the accelerated rate of change: the topics of interest evolve as the pandemic progresses and the scientific ...
arxiv  

Young Male and Female Scientists: A Quantitative Exploratory Study of the Changing Demographics of the Global Scientific Workforce [PDF]

arXiv, 2023
In this study, the global scientific workforce is explored through large-scale, generational, cross-sectional, and longitudinal approaches. We examine 4.3 million nonoccasional scientists from 38 OECD countries publishing in 1990-2021. Our interest is in the changing distribution of young male and female scientists over time across 16 STEMM (science ...
arxiv  

Promoting Equity in Health Information: Partners for Health Information and Health Information Partners (HIPS) [PDF]

, 2006
In 2004, a community health outreach partnership, funded by the U.S. National Library of Medicine (NLM), was launched. HIPS, Health Information Partners, promoted health literacy and health advocacy for residents of Washington, D.C., who frequented the ...
Billingsley, Richard, Gardiner, Betsy, Pezo, Eduardo, Pomerantz, Karyn L., Wilson, Patricia   +4 more
core   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Descriptive Analysis of a Baseline Concussion Battery Among U.S. Service Academy Members: Results from the Concussion Assessment, Research, and Education (CARE) Consortium [PDF]

, 2018
Introduction The prevalence and possible long-term consequences of concussion remain an increasing concern to the U.S. military, particularly as it pertains to maintaining a medically ready force.
Allred, C. Dain, Broglio, Steven P., Cameron, Kenneth L., Campbell, Darren E., D'Lauro, Christopher J., Houston, Megan N., Johnson, Brian R., Kelly, Tim F., McAllister, Thomas, McCrea, Michael, McGinty, Gerald, O'Connor, Kathryn L., O'Donnell, Patrick G., Pasquina, Paul, Peck, Karen Y., Svoboda, Steven J.   +15 more
core   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source