Results 61 to 70 of about 3,273,344 (325)

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

open access: yesMolecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu   +3 more
wiley   +1 more source

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

open access: yesMolecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld   +7 more
wiley   +1 more source

Los CaCCs: proteínas multifuncionales, de la fisiología a la enfermedad

open access: yesCiencia Ergo Sum, 2019
Los CaCCs son proteínas formadoras de poros que se ubican en la membrana celular. Los CaCCs permiten el paso de iones a través de la membrana, lo cual es clave para una adecuada realización de funciones celulares y para el desarrollo de algunas ...
Juan A. Contreras-Vite   +2 more
doaj   +1 more source

Zero-Shot and Few-Shot Classification of Biomedical Articles in Context of the COVID-19 Pandemic [PDF]

open access: yesarXiv, 2022
MeSH (Medical Subject Headings) is a large thesaurus created by the National Library of Medicine and used for fine-grained indexing of publications in the biomedical domain. In the context of the COVID-19 pandemic, MeSH descriptors have emerged in relation to articles published on the corresponding topic.
arxiv  

The Scientific Competitiveness of Nations [PDF]

open access: yesPLoS ONE 9(12): e113470 (2014), 2014
We use citation data of scientific articles produced by individual nations in different scientific domains to determine the structure and efficiency of national research systems. We characterize the scientific fitness of each nation (that is, the competitiveness of its research system) and the complexity of each scientific domain by means of a non ...
arxiv   +1 more source

Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance

open access: yesMolecular Oncology, EarlyView.
In this research, we analyzed the relationship between gut microbiota and tumor. We discovered that both subcutaneous and metastatic tumors would alter the composition and metabolic function of gut microbiota. Meanwhile, fecal microbiota transplantation also indicated the anti‐tumor role of the gut microbiota, revealing the crosstalk between tumor and ...
Siyuan Zhang   +8 more
wiley   +1 more source

Systematic analysis of agreement between metrics and peer review in the UK REF [PDF]

open access: yesPalgrave communications (2019), 5(1), 29, 2018
When performing a national research assessment, some countries rely on citation metrics whereas others, such as the UK, primarily use peer review. In the influential Metric Tide report, a low agreement between metrics and peer review in the UK Research Excellence Framework (REF) was found. However, earlier studies observed much higher agreement between
arxiv   +1 more source

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

open access: yesMolecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy   +12 more
wiley   +1 more source

SAFETY OF HOSPITALIZED ELDERLY PATIENTS: AN INTEGRATIVE LITERATURE REVIEW

open access: yesCogitare Enfermagem, 2016
The objective was to identify how the safety of hospitalized elderly patients has been discussed in the scientific literature. An integrative literature review was undertaken in the databases Literatura Latino Americana e do
Thayane Dias dos Santos   +3 more
doaj   +1 more source

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