Results 71 to 80 of about 3,273,344 (325)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Septicemia in a Neonate following Therapeutic Hypothermia: The Literature Review of Evidence

Case Reports in Pediatrics, 2013
We report a term neonate with hypoxic ischemic encephalopathy who underwent a 72-hour therapeutic hypothermia. He developed unstable body temperature associated with coagulase negative staphylococcus septicemia 2 weeks later which was promptly treated ...
Kam Lun Hon, Joshua J. X. Li, Bernadette L. Y. Cheng, Alexander K. C. Leung   +3 more
doaj   +1 more source

Prevalence of body weight dissatisfaction among adolescents: a systematic review

Revista Paulista de Pediatria, 2022
Objective: To identify the prevalence of weight dissatisfaction among adolescents aged 10-19 years and stratify the analysis by sex. Data source: A literature review of cross-sectional studies among healthy adolescents was performed. The U.S. National
Mariana Contiero San Martini, Daniela de Assumpção, Marilisa Berti de Azevedo Barros, Josiemer Mattei, Antônio de Azevedo Barros Filho   +4 more
doaj   +1 more source

An analysis of the evolution of science-technology linkage in biomedicine [PDF]

Journal of Informetrics 14, 101074 (2020), 2019
Demonstrating the practical value of public research has been an important subject in science policy. Here we present a detailed study on the evolution of the citation linkage between life science related patents and biomedical research over a 37-year period.
arxiv   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

About the MeSH information and retrieval query language in the area of activity of Polish academic libraries of medical universities

Forum Bibliotek Medycznych
The article presents the history of MeSH, the information and retrieval query language in Poland, in the context of cooperation between academic medical libraries. It also discusses the role of the Central Medical Library in the implementation of medical
Magdalena Kotlarek-Naskręt
doaj   +1 more source

The effect of national and international multiple affiliations on citation impact [PDF]

arXiv, 2020
Researchers affiliated with multiple institutions are increasingly seen in current scientific environment. In this paper we systematically analyze the multi-affiliated authorship and its effect on citation impact, with focus on the scientific output of research collaboration. By considering the nationality of each institutions, we further differentiate
arxiv  

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

Qualitative Research: Key Concepts and a Brief Overview of Its Application in Geriatrics/Gerontology [PDF]

Geriatrics, Gerontology and Aging
INTRODUCTION: This paper is part of a special series designed to help health professionals to develop a research project. It reviews the importance, methodology, and applicability of qualitative research.
Aline Figueiredo Falcão Cyriaco, Danny Nunn, Rivadávio Fernandes Batista de Amorim, Denise Pinheiro Falcão, Heitor Moreno   +4 more
doaj   +1 more source