A Metal‐Free Carbon Monoxide Prodrug Suppresses Metastasis of Pancreatic and Breast Cancer
A metal‐free carbon monoxide (CO) prodrug, CO‐116, delivers controlled systemic CO without inhalation. CO suppresses the HRG1–heme axis, reducing intracellular heme availability. Attenuation of this pathway inhibits metastatic progression in pancreatic and triple‐negative breast cancer models.
Tiantian Zhang +15 more
wiley +1 more source
Designing a national framework for preventing fraud in Iran's health system: a sequential mixed-methods study using qualitative analysis and Delphi consensus. [PDF]
Vafaee Najar A, Hooshmand E.
europepmc +1 more source
Triple‐negative breast cancer has a poor prognosis. Xanthatin directly targets and degrades CISD1, triggering ferroptosis through iron dysregulation. The concurrently activated mitophagy synergistically amplifies ferroptotic cell death. Xanthatin also demonstrates potent in vivo anti‐tumor efficacy with minimal toxicity, highlighting its therapeutic ...
Qinwen Liu +9 more
wiley +1 more source
Lightweight robust detection of anthropogenic floating debris in turbid and dynamic aquatic environments via enhanced feature fusion. [PDF]
Zhong Y +8 more
europepmc +1 more source
identifier:https://repository.tku.ac.jp/dspace/handle/11150 ...
openaire
This study firstly presents a comprehensive and high‐resolution pan‐3D genome resource in chicken. Our findings reveal the role of structural variations in 3D genome architectures, and how they influence the domestication process and production traits at the 3D genome level.
Zhen Zhou +19 more
wiley +1 more source
Assessing semantic interoperability in environmental sciences: variety of approaches and semantic artefacts. [PDF]
Di Muri C +9 more
europepmc +1 more source
Recent antitrust developments in the European Community. Address by Willy Christoph Schlieder, Director-General for Competition, to the Association of the Bar of the City of New York. New York, 31 March 1976 [PDF]
Schlieder, Willy Christoph.
core
Evaporation‐Driven Solutal Marangoni Control of Rayleigh–Taylor Instability in Inverted Films
Inverted liquid films, like paint on a ceiling, are inherently unstable under gravity. This work shows that selective evaporation in volatile binary mixtures generates solutal Marangoni stresses that either suppress or amplify the Rayleigh Taylor instability.
Minwoo Choi, Hyejoon Jun, Hyoungsoo Kim
wiley +1 more source

