Results 141 to 150 of about 6,946,553 (358)

Transatlantic consumptions: disease, fame and literary nationalisms in the Davidson sisters, Southey, and Poe. [PDF]

open access: yes, 2003
This article supplements Lawlor’s Consumption and Literature by demonstrating the complex relationships between disease and literature. Lawlor shows how the consumptive American poetesses, sisters Margaret and Lucretia Davidson, became famous for their ...
Lawlor, Clark
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Tożsamość kulturowa w rusińskiej literaturze na Słowacji

open access: yesPostscriptum Polonistyczne, 2020
Cultural identity is a very important part of national identity, as it defines the individual’s place in society. The aim is to show the Rusyn national identity consolidated in the contemporary literary works and to define the symbolism used by the Rusyn
Ivana Slivková
doaj  

Systems of innovation [PDF]

open access: yes
We review the literature on national innovation systems. We first focus on the emergence of the concept of innovation systems, reviewing its historical origins and three main flavours (associated to three “founding fathers†of the concept). After this,
B. Verspagen, Bas ter Weel, L. Soete
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Beyond cultural and national identities : current re-evaluation of the Kominka literature from Taiwan\u27s Japanese period

open access: yes, 1997
This paper is an offshoot of a larger, ongoing project that intends to deal with the relationship between various artistic formations and the dominant culture in Taiwan\u27s post-1949 era. Though the lifting of martial law in 1987 has demarcated this era
CHANG, Sung Sheng, Yvonne
core  

Effects of New Zealand general elections on stock market returns [PDF]

open access: yes, 2010
This paper examines stock returns under both National and Labour governments in New Zealand, offering further insight into the existence of the political cycle effect.
Abidin, Sazali Zainal   +2 more
core  

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

open access: yesFEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz   +9 more
wiley   +1 more source

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