Results 51 to 60 of about 1,526,435 (309)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Mental health symptoms and discrimination among immigrant and US-born Hispanic or Latino adults during the COVID-19 pandemic

BMC Psychology
Background Mental health symptoms are highly stigmatized, potentially increasing the risk of experiencing discrimination, particularly within minoritized communities such as Hispanic or Latino populations.
Emmanuel A. Odame, Maryam Elhabashy, David Adzrago, Jolyna Chiangong, Cameron K. Ormiston, Faustine Williams   +5 more
doaj   +1 more source

COVID-19 vaccination willingness and uptake among low-income Black/African American, Latino, and White adults living in the U.S

Preventive Medicine Reports, 2023
The purpose of this study was to assess differences in COVID-19 vaccine willingness and uptake between low-income and non-low-income adults and across race-ethnicity.
Alexis L. Green, Anita L. Stewart, Anna M. Nápoles, Paula D. Strassle   +3 more
doaj   +1 more source

Estonia: a model for interwar Europe? [PDF]

, 2015
While Estonia’s 1925 Law on Cultural Self-Government for National Minorities is often cited as a rare functioning example of Renner and Bauer’s non-territorial autonomy scheme, there has until recently been comparatively little research on how the law ...
Smith, David J.
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Internal Migration of Ethnic Groups in England and Wales by Age and District Type [PDF]

, 2008
This paper examines how internal migration propensities vary by age and ethnic group using data from level 1 (district) scale in England and Wales extracted from the 2001 Census Special Migration Statistics and from tables specially commissioned from the
Hussain, S., Stillwell, J.
core  

The limits of social class in explaining ethnic gaps in educational attainment [PDF]

, 2011
This paper reports an analysis of the educational attainment and progress between age 11 and age 14 of over 14,500 students from the nationally representative Longitudinal Study of Young People in England (LSYPE).
Abbott D., Caplan C., Coleman J. S., Cook P. J., DES, DfES, Fryer R. G., Gillborn D., Hedges L. V., Kenway P., KewalRamani A., Modood T., Phillips M., Powdthavee N., Sewell T., Sirin S. R., Steve Strand, Strand S., Swann Report, Sylva K., US Census Bureau, Wilson D.   +21 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Territorial-Administrative Decentralisation and Ethnocultural Diversity in Ukraine: Addressing Hungarian Autonomy Claims in Zakarpattya [PDF]

, 2016
The paper argues firstly that, since there is no obvious separatist movement within Zakarpattya, the Ukrainian state should seek as far as possible to accommodate Hungarian identity claims within the region (and those of other smaller minority ...
Semenyshyn, Mariana, Smith, David J.
core  

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source