Results 41 to 50 of about 1,914,536 (263)

Engineering a safe and potent LNP-mRNA delivery system by leveraging the dual activities of α-tocopherol

International Journal of Pharmaceutics: X
The widespread application of lipid nanoparticles (LNPs) as mRNA delivery vectors is constrained by the intrinsic trade-off between delivery efficacy and inflammatory reactogenicity.
Huijun Wang, Ziyao Kang, Xiaoshuang Wang, Zheng Pan, Yun Sun, Yuan Li, Xin Li, Shuai Shao, Xiang Zheng, Zibo Han, Jin Ren   +10 more
doaj   +1 more source

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source

Single-cell omics data-driven decoding of tumor clonal evolution through reinforcement learning

Genome Medicine
Background Tumor evolution is driven by substantial cellular heterogeneity, yet its reconstruction remains challenging with conventional bulk sequencing approaches.
Qiushun He, Zhilong Zhang, Yuanmei Wang, Xinghao Du, Chenxi Xie, Yueyuxiao Yang, Huanming Yang, Yang Yu, Meng Yang   +8 more
doaj   +1 more source

Detection of PrPBSE and prion infectivity in the ileal Peyer’s patch of young calves as early as 2 months after oral challenge with classical bovine spongiform encephalopathy

Veterinary Research, 2017
In classical bovine spongiform encephalopathy (C-BSE), an orally acquired prion disease of cattle, the ileal Peyer’s patch (IPP) represents the main entry port for the BSE agent.
Ivett Ackermann, Anne Balkema-Buschmann, Reiner Ulrich, Kerstin Tauscher, James C. Shawulu, Markus Keller, Olanrewaju I. Fatola, Paul Brown, Martin H. Groschup   +8 more
doaj   +1 more source

Campus Novels and the Nation of Peers [PDF]

American Literary History, 2014
This article covers an entire generation of American popular novels published between the Civil War and World War I: campus fictions, focusing all but exclusively on homosocial scenes of undergraduate merriment. Centering on the camaraderie of fraternal sociality, campus novels model friendship as a democratic ideal for dispensing with conflict ...
openaire   +1 more source

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye, Chimezie Okwuonu, Evelyn Idam, Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Zinnah Aloziem, Blossom Amamchukwu, Patience Elimia, Mkpoikanabasi Obot‐Obot, Henry Mbakwe, Praises Maduagwuna, Olatunji Akinrodoye, Chiamaka Anyanwu, Benjamin Anyanwu, Adedamola Akinsiku, Oluwatoyin A. Akinsiku, Muzamil O. Hassan, Fatiu A. Arogundade, Olalekan E. Ojo, Homayemem Weli, Jesupelumi Adenihun, Aderemi Adelaja, Ebun Bamgboye, Olalekan Olatise, Ade E. Faponle, Ayoola Odeyemi, Michael Muoka, Stephen Asaolu, Qudrat Busari, Blessing Dawudu, Michael Naiyeju, Rasheed A. Balogun   +33 more
wiley   +1 more source

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

CONSTRUCTION OF NATION AND NATIONALISM IN 4 INDONESIAN NOVELS IN EUROPE

Widyaparwa, 2020
This study aims to understand the concept of nation and nationalism through four literary works with a European background. The approach of literary sociology in this study is used to look for forms of Indonesian nationalism in Europe. The aim is to find the source of self-depiction as an important element in constructing the concept of the nation. The
Candra Rahma Wijaya Putra, Rose Fitria Lutfiana   +1 more
openaire   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

National Novel and New Architecture [PDF]

, 2019
AbstractThis book traces the relationship between the novel and architecture in Italy during the Fascist regime (1922–1943). Our analysis reveals how common aesthetic principles underpinned the development of these superficially very different artistic forms.
Francesca Billiani, Laura Pennacchietti
openaire   +1 more source