Results 71 to 80 of about 6,597 (209)

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source

Generation of Nasal Cell‐Derived Human Alveolar Organoids and Organoid‐Macrophage Assembloids for in Vitro Lung Modeling

Advanced Science, EarlyView.
This study demonstrates the generation of human alveolar organoids from nasal cells, which, when co‐cultured with monocyte‐derived macrophages, promotes maturation of both components and forms alveolar assembloids resembling native alveoli. These alveolar organoids and assembloids offer accessible, physiologically relevant in vitro systems for ...
Man Chun Chiu, Shuxin Zhang, Cun Li, Yifei Yu, Zhixin Wan, Jingjing Huang, Wei Xue, Ying Zhou, Xiaoxin Zhu, Qiaoshuai Lan, Jiali Wu, Zijun Zhao, Yuhong Liu, Xinjie Meng, Lin Huang, Hin Chu, Honglin Chen, Kelvin Kai‐Wang To, Kwok Yung Yuen, Jie Zhou   +19 more
wiley   +1 more source

Strategi Mencapai Penghidupan Berkelanjutan Pada Sektor Pariwisata Suku Tengger di Taman Nasional Bromo Tengger Semeru

Jurnal Kepariwisataan, 2020
Sustainable livelihood is a concept achieved through strategies for utilizing livelihood assets natural, human, social, physical, and financial (DFID, 2001; Scoones, 2009; and Ellis, 2000).
Muhammad Irsyad, Siti Nurul Rofiqo Irwan, Sri Rahayu Budiani   +2 more
doaj   +1 more source

Molecular Engineering of Polytriphenylamine: A Fluorinated Cathode for High‐Voltage, Ultrafast, and Stable Sodium‐Ion Batteries

Advanced Energy Materials, EarlyView.
Fluorination of polytriphenylamine lowers the HOMO energy, enabling high‐voltage operation of the PFTPA cathode. Electron‐withdrawing F substituents stabilize the nitrogen redox center and suppress polarization, leading to fast kinetics. The optimized polymer delivers ∼3.75 V vs.
Natalia Voronina, Irina A. Chuyko, Michael D. Khitrov, Koji Yazawa, Hitoshi Yashiro, Yuriy N. Luponosov, Seung‐Taek Myung   +6 more
wiley   +1 more source

Human activities and forest fires in Indonesia: An analysis of the Bromo incident and implications for conservation tourism

Trees, Forests and People
This study delves into the Bromo magnitude of the fire incident in Indonesia, a notable tourism destination, uncovering significant gaps in knowledge regarding tourist-induced forest fires.
Sapta Suhardono, Laili Fitria, I Wayan Koko Suryawan, Iva Yenis Septiariva, Rachmat Mulyana, Mega Mutiara Sari, Nova Ulhasanah, Wisnu Prayogo   +7 more
doaj   +1 more source

APPLICATION OF DIGITAL DESIGN OF TOURISM CENTRE OF SENDURO IN BROMO - TENGGER - SEMERU NATIONAL PARK, INDONESIA

BORDER
Instagram able places is a new trend before the Covid-19 pandemic. The theory of Instagram able places has not yet developed in the Architectural field. Several business-related studies have proposed the use of social media, especially Instagram, to attract tourists to attractions.
Oktafiana, Brina, TJANDRA, CYNTHIA, Tanuwidjaja, Gunawan, Wijaya, Elvina Shanggrama, Adiasih, Priskila   +4 more
openaire   +1 more source

Impact of forest fires in bromo national park: Analysis of the environment and recovery efforts

Jurnal Bisnis Kehutanan dan Lingkungan
Background: Forest fires represent natural disasters that often stem from environmental conditions, including events like El Niño or extreme climatic situations. Rainfall, a crucial factor, plays a role in influencing extreme climate occurrences. In Indonesia, human activities predominantly contribute to forest fires, exacerbated by extreme climatic ...
openaire   +1 more source

The sloping agricultural land management on buffer zone of Bromo Tengger Semeru National Park in Malang Regency

IOP Conference Series: Earth and Environmental Science, 2019
The land management in the buffer zone of the protected area has been considered important to support biodiversity in the conservational area. Many areas in the buffer zone of Bromo Tengger Semeru National Park (BTSNP) in Malang Regency, Indonesia, have been threatened by improper agricultural activity.
T N Kholilah, H Rahimah, R Hamzah, A Arifianto, C Retnaningdyah, L Hakim   +5 more
openaire   +1 more source

Autoreactivity Versus Autoimmunity: Characteristics of Autoantigen‐Specific CD4 T Cells in Rheumatoid Arthritis and Health

Arthritis &Rheumatology, EarlyView.
Objective CD4 T cells specific for citrullinated (cit) peptides are key players in rheumatoid arthritis (RA) immunopathogenesis. Characterizing these cells and identifying features of healthy and RA‐associated autoreactivity will provide valuable insight into disease mechanisms and form the basis of immune state biomarkers to facilitate the next ...
James A. Stanway, Daniel Peters, Helen Waller, Jeremy Lakey, Henrique De Paula Lemos, Kristian Williams, Abbie Degnan, Julie Diboll, Abdul Mannan Baru, David Tough, Arthur G. Pratt, Catharien M.U. Hilkens, Amy E. Anderson, John D. Isaacs   +13 more
wiley   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source