Results 91 to 100 of about 5,764,973 (300)

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Migration of Wintering Grey Plover From Southeast Asia to North‐Central Siberia Challenges Breeding Population Delineations in Russia

Ecology and Evolution
Shorebird populations are declining across the world due to factors such as habitat loss and climate change. Identification of shorebird migration routes and important stopover sites can facilitate the implementation of strategic and effective ...
David Li, Max De Yuan Khoo, Richard B. Lanctot, Pavel S. Tomkovich, Zhijun Ma, Jun Rui Chow, Malcolm Chu Keong Soh, Shufen Yang, Choon Beng How, Adrian Loo, Robert Teo, Liang Jim Lim, Chee Chiew Leong, Kenneth Boon Hwee Er   +13 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Spatial patterns and influencing factors of accessibility to national-level protected areas in China [PDF]

Ziyuan Kexue
[Objective] This study analyzes the accessibility to various types of protected areas and their influencing factors at the national scale, aiming to provide a basis for balancing ecological conservation and development utilization in these areas ...
YANG Wenyue, CHEN Yani, CONG Yanguo
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Landbird trends in protected areas using time‐to‐event occupancy models

Ecosphere, 2019
Global populations of wildlife are affected by human activity, land cover change, and climate change. Long‐term monitoring programs across large spatial scales are required to understand how these and other factors affect wildlife populations.
Jesse Whittington, Brenda Shepherd, Anne Forshner, Julien St‐Amand, Jennifer L. Greenwood, Cameron S. Gillies, Barb Johnston, Rhonda Owchar, Derek Petersen, James Kimo Rogala   +9 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Nocardia seriolae and Streptococcus iniae Co‐Infection in Cultured Fourfinger threadfin, Eleutheronema tetradactylum, in Singapore

Aquaculture, Fish and Fisheries
Between April and May 2021, two batches of diseased fourfinger threadfin (Eleutheronema tetradactylum) from an open‐sea net cage farm were submitted for diagnostic post‐mortem examination.
Biyun Ching, Xuan Hui Teo, Christine Hui En Lee, Alvin Wee, Angeline Lua, Yih Hong Tay, Wai Kwan Wong, Charlene Judith Fernandez, Diana Chee, Kelvin Lim, Siow Foong Chang   +10 more
doaj   +1 more source

Revisiting Leopold: Resource Stewardship in the National Parks

, 2014
The US National Park System is significantly different – in scope, number of units, size and complexity – than in the 1960s when the Leopold Report. Scientific understanding of natural and cultural resources has expanded dramatically.
R. Colwell, Susan Avery, J. Berger, G. E. Davis, H. Hamilton, T. Lovejoy, S. Malcom, Ann McMullen, M. Novacek, Richard J Roberts, R. Tapia, G. Machlis   +11 more
semanticscholar   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source