Results 61 to 70 of about 5,764,973 (300)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Suid-Afrika se nasionale parke sisteem – wat van die toekoms?

open access: yesKoedoe: African Protected Area Conservation and Science, 1977
The significance of the 50th anniversary of the National Parks Board of Trustees is highlighted and homage is paid to all those who have contributed to the development of the national parks system in the Republic of South Africa.
Sy Edele H. Schoeman
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Increasing role of tourism in Finnish national parks

open access: yesFennia: International Journal of Geography, 2008
While the role of traditional livelihoods has decreased, tourism has become an important tool for regional development in northern peripheral areas, and the economic and political expectations have increased. National parks have become attractive tourist
Riikka Puhakka
doaj  

Climate and vegetation in a semi-arid savanna: Development of a climate–vegetation response model linking plant metabolic performance to climate and the effects on forage availability for large herbivores

open access: yesKoedoe: African Protected Area Conservation and Science, 2012
A framework to establish the expected effects of climate on forage quantity and quality in a local savanna system was developed to interpret large herbivore population performance patterns in the Kruger National Park.
Armin H. Seydack   +5 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Evolving Values and How They Have Shaped the United States National Park System

open access: yesBuilt Heritage, 2018
As one of the oldest and best-known park systems, the US National Park System continues to influence park systems around the world. However, the origins and wide diversity of US national parks are often not fully understood as there is a long-lived ...
Cari Goetcheus   +2 more
doaj   +1 more source

Investigating the Effect of National Park Sustainability on National Park Behavioral Intention: Kinabalu National Park

open access: yesProcedia Economics and Finance, 2016
AbstractNational Park Sustainability (NPSus) is an important construct in the context of national parks which will lead tourism industry to move towards sustainable national parks. Although previous studies examined the tourist behavioral intention through deployment of sustainability principles or destination sustainability, there is a lack of ...
Mihanyar, Payam   +2 more
openaire   +1 more source

National Parks in Northern Sweden as Refuges for Illegal Killing of Large Carnivores

open access: yes, 2016
Large protected areas are often considered to be as important as population size in reducing extinction risk for large carnivores. However, the effectiveness of protected areas for large carnivore survival has rarely been tested where surrounding areas ...
G. Rauset   +6 more
semanticscholar   +1 more source

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