Results 61 to 70 of about 18,940,833 (282)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Social assessment of national parks through the example of the Aggtelek National Park

Hungarian Geographical Bulletin, 2022
Karst areas, which are less involved in productive activities are often declared protected areas that can have a positive impact on the lives of the local communities.
Margit Kőszegi, Alena Gessert, Janetta Nestorová-Dická, Péter Gruber, Zsolt Bottlik   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Searching for common ground, a scientific approach to subjective environmental impact assessments: an example from the Kgalagadi Transfrontier Park

Koedoe: African Protected Area Conservation and Science, 2003
In order to break away from the frequent subjective nature of assessing potential environmental impacts and alternative scenarios when undertaking new developments a structured scientific approach was adopted in the present analysis. An assessment of the
J.G. Castley, H. Bezuidenhout, M.H. Knight   +2 more
doaj   +1 more source

The influence of the COVID‐19 pandemic on the demand for different shades of green

People and Nature, 2022
COVID‐19 has heightened the dependence of urban dwellers on cultural ecosystem services provided by urban green spaces (UGS), specifically in regard to the provision of recreational opportunities, and psychological and physical health benefits arising ...
Kathleen K. L. Yap, Malcolm C. K. Soh, Angelia Sia, Wei Jun Chin, Sophianne Araib, Wei Ping Ang, Puay Yok Tan, Kenneth B. H. Er   +7 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Exploring the economic impact of national parks on the local economy. Functional approach in the context of Poland’s transition economy [PDF]

Human Geographies: Journal of Studies and Research in Human Geography, 2016
The article presents the methodological assumptions in functional approach for exploring the economic impact of national parks on the local economy. The original model of systemic analysis proposed and discussed in the article allows the broad spectrum ...
Mirosław Mika, Bernadetta Zawilinska, Robert Pawlusinski   +2 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Environmental DNA Biosurveillance of Chelonid Herpesvirus 5 (ChHV5) in Endangered Sea Turtles Around Singapore

Environmental DNA
Sea turtle fibropapillomatosis (FP) is a potentially debilitating and neoplastic disease closely associated with the aetiological agent chelonid herpesvirus 5 (ChHV5).
Yin Cheong Aden Ip, Li Ying Tan, Chee Wai Lee, Jing Chen, Ravendrakumar Shanmugavelu Balasubramaniam, Muhammad Faizal Sim, Collin Hor Yee Tong, Jerome Yong, Yifan Wang, Xuan Hui Teo, Christine H. E. Lee, Zi Yan Brian Tan, Charlene Judith Fernandez, Siow Foong Chang, Kenneth B. H. Er   +14 more
doaj   +1 more source