Results 71 to 80 of about 19,484,014 (261)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Texas Savings and Loan Department Sixty-Third Annual Report of Savings and Loan Associations

open access: yes, 1992
Annual report related to savings and loan associations in the state of Texas including general statistics and financial information, changes in charter authorizations, and individual branch ...
Texas. Savings and Loan Department.
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Rural financial savings mobilization in Sri Lanka: Bottlenecks and reform proposals [PDF]

open access: yes
The objective of the following study is to evaluate rural deposit mobilization programmes in Sri Lanka, to identify major bottlenecks in the national savings system, and to provide recommendations for improving rural (financial) savings mobilization for ...
Fischer, Bernhard
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Travel Distance Between Participants in US Telemedicine Sessions With Estimates of Emissions Savings: Observational Study

open access: yesJournal of Medical Internet Research
BackgroundDigital health and telemedicine are potentially important strategies to decrease health care’s environmental impact and contribution to climate change by reducing transportation-related air pollution and greenhouse gas ...
Mollie R Cummins   +14 more
doaj   +1 more source

Utworzenie Kasy Oszczędności w Wolnym Mieście Krakowie i jej działalność w latach 1844-1857

open access: yesCzasopismo Prawno-Historyczne, 2018
The article presents the activity of the Savings Bank in Cracow between 1844 and 1857. It recreates the course of works undertaken during its creation by the Representatives Assembly.
Mateusz Mataniak
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

An Empirical Investigation of the Determinants of Oman's National Savings [PDF]

open access: yes
In this note we examine the determinants of Oman's national savings for the period 1977-2003 using the bounds testing approach to cointegration. We use the ARDL model to estimate the long run and short run determinants of national savings.
Saud AL Siyabi, Paresh Narayan
core  

Retail Savings Market During Digitalization

open access: yesВестник Кемеровского государственного университета. Серия: политические, социологические и экономические науки
Investments constitute a fundamental component of most global economies. A primary strategic objective for Russia involves mobilizing idle financial resources and allocating them across all economic sectors.
El'kin Vladslav, Kalacheva Irina
doaj   +1 more source

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