Results 31 to 40 of about 1,412,017 (312)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

POLAND'S NATIONAL SECURITY POLICY IN A NEW REGIONAL SECURITY ENVIRONMENT. CASE STUDY: NATIONAL SECURITY STRATEGY OF POLAND (2014)

open access: yesTorun International Studies, 2018
Military aggression conducted by Russia against Ukraine was a turning point on the scene of international relations, and, particularly, in Europe. The Russian aggression against Ukraine, completed by the illegal occupation and annexation of the Crimean ...
Anton Moldovan
doaj   +1 more source

Technology, Strategy and National Security

open access: yesTechnology and Culture, 1988
Shipping list no.: 85-916-P. ; Includes bibliographical references and index. ; Mode of access: Internet.
Sanders, Ralph.   +2 more
openaire   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

CANADA AND ECONOMIC SECURITY: THE WAY AHEAD

open access: yesThe Journal of Intelligence, Conflict and Warfare
In August-September 2024, Global Affairs Canada held public consultations on “Potential New Measures to Advance and Defend Canada’s Economic Security Interests.” The inputs provided will help the Government of Canada update or develop approaches and ...
Stéphane Lefebvre
doaj   +1 more source

Some aspects of internal security policy as an element of the national security strategy of the Republic of Serbia [PDF]

open access: yesZbornik Radova: Pravni Fakultet u Novom Sadu, 2017
The establishment or reorganization of the national security system is always based on certain strategic and legal acts that determine organization, competencies, powers, coordination, cooperation, control and other issues relevant for the work of the ...
Stajić Ljubomir S.   +2 more
doaj  

France’s National Security Strategy [PDF]

open access: yes, 2011
France is one of the EU member states with a most highly-developed national strategic culture. Victory in the Second World War, its role as a member of the United Nations Security Council, the development of a nuclear programme that gave the country the ...
Blain, Camille, Liberti, Fabio
core  

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

open access: yesMolecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor   +2 more
wiley   +1 more source

¿Sobrevivirá el Plan Mares al Plan Integral de Seguridad Marítima? La falta de doctrina estratégica española hacia el área del Estrecho de Gibraltar

open access: yesPaix et Sécurité Internationales, 2019
The approval of new Maritime Security Action Plan by National Security Council addresses the need to review previous Maritime Security Integral Plan for Strait of Gibraltar, entitled MARES Plan, with the aim of developing a Maritime Security Plan ...
Luis Romero Bartumeus
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

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