Results 61 to 70 of about 2,416,964 (304)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Social Security Programs Throughout the World: Africa, 2011 [PDF]
, 2011 [Excerpt] This third issue in the current four-volume series of Social Security Programs Throughout the World reports on the countries of Africa. The combined findings of this series, which also includes volumes on Europe, Asia and the Pacific, and the ...
International Social Security Association +1 more
core +2 more sources
Molecular Oncology, EarlyView.Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor +2 more
wiley +1 more source
Critical Infrastructure in the National Security System
Safety & Fire Technology, 2019 Aim: To present relationships resulting from legal regulations impacting the effectiveness of critical infrastructure protection, which is a part of the national security system.
Bogdan Kosowski
doaj +1 more source
Handbook of Emergency Management For State-Level Transportation Agencies, MTI Report 09-10 [PDF]
, 2010 The Department of Homeland Security has mandated specific systems and techniques for the management of emergencies in the United States, including the Incident Command System, the National Incident Management System, Emergency Operations Plans, Emergency
Edwards, Frances L., Goodrich, Daniel C.
core +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
National Energy Security: Implications for National Energy Policy [PDF]
, 2001 The Environmental and Energy Study Institute and Senator Susan Collins (R-ME) co-hosted a Congressional briefing to examine the nation's current energy system and its vulnerabilities, as well as some of the steps and solutions to providing the nation and
Amy Brooks
core
"Food System Mapping in Kanyanya (Kampala)" - Workshop Report. [PDF]
, 2020 Food value chains are part of the systemic drivers of urban food and nutrition security. An important part of these value chains are the various informal small actors. These include producers, transporters, processors and retailers.
Dijkxhoorn, Y. +4 more
core
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source