Results 101 to 110 of about 334,751 (298)

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Determinants of Low Coverage of the Free Surgical Care Programme for Trachomatous Trichiasis in Rural Guinea in 2022

Tropical Medicine and Infectious Disease
This study aimed to describe the experiences of healthcare personnel and patients in the organization of free surgical campaigns and care for trachomatous trichiasis in the health district of Siguiri in Guinea, including challenges experienced in ...
Lamine Lamah, Delphin Kolié, Akoi Zoumanigui, Nouhou Konkouré Diallo, Mamadou Camara, Hawa Manet, Tamba Mina Millimouno, Bienvenu Salim Camara, Aissata Tounkara, Alexandre Delamou   +9 more
doaj   +1 more source

Surgical Technical Evidence Review for Elective Total Joint Replacement Conducted for the AHRQ Safety Program for Improving Surgical Care and Recovery

Geriatric Orthopaedic Surgery & Rehabilitation, 2018
Background: Use of enhanced recovery pathways (ERPs) can improve patient outcomes, yet national implementation of these pathways remains low. The Agency for Healthcare Research and Quality (AHRQ; funder), the American College of Surgeons, and the Johns ...
Christopher P. Childers MD, Anaar E. Siletz MD, PhD, Emily S. Singer MD, Claire Faltermeier PhD, Q. Lina Hu MD, Clifford Y. Ko MD, MS, MSHS, Gregory J. Golladay MD, Stephen L. Kates MD, Elizabeth C. Wick MD, Melinda Maggard-Gibbons MD, MSH   +9 more
doaj   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Assessment of surgical capacity and productivity in high-volume Ethiopian hospitals: mixed method study

BMC Health Services Research
Background In Ethiopia and other low-and middle-income countries, access to emergency and elective surgical care is still inadequate and inequitable.
Amare Hailekiros Gebregzi, Elubabor Buno Teko, Abiy Dawit Tantu, Natinael Tesfaye Jale, Genanaw Kassie Getahun, Yohannes Molla Asemu   +5 more
doaj   +1 more source

Medial closing wedge distal femoral osteotomy with patient-specific instrumentation: surgical technique, accuracy, and preliminary outcomes

Frontiers in Surgery
Introduction and aimMedial closing wedge distal femoral osteotomy (MCW-DFO) is a surgical technique used to treat symptomatic valgus knee deformity. This retrospective study aims to evaluate the reliability of Patient-Specific Instrumentation (PSI) in ...
Leonardo Puddu, Giovanni Lugani, Francesco Perusi, Hansheng Deng, Tianfeng Zhu, Francesco Pisanu, Edoardo Fantinato, Stefano Pescia, Andrea Fabio Manunta, Andrea Fabio Manunta, Carlo Doria, Carlo Doria, Fabrizio Cortese, Gianfilippo Caggiari, Gianfilippo Caggiari   +14 more
doaj   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +15 more
wiley   +1 more source

Preferences for Posttraumatic Osteoarthritis Prevention Strategies in Individuals With Anterior Cruciate Ligament Injury

Arthritis Care &Research, EarlyView.
Objective There is growing interest in evaluating new strategies to delay or prevent posttraumatic osteoarthritis (PTOA) in individuals who have sustained anterior cruciate ligament (ACL) injury. This study sought to determine characteristics of potential treatments that are acceptable to patients with ACL injury. Methods Participants with a history of
Kevin Kennedy, Lily Waddell, Adam Easterbrook, Jeffrey N. Katz, Cale Jacobs, Morgan Jones, Faith Selzer, Elena Losina, Liana Fraenkel, Nick Bansback   +9 more
wiley   +1 more source

Investment in family medicine to improve health outcomes in sub-Saharan Africa

African Journal of Primary Health Care & Family Medicine
Family physicians (FPs), as educators, capacity builders and clinical governance leaders of primary care (PC) teams, work to make them more effective and responsive to the needs of their patients.
Sunanda C. Ray, Mpundu Makasa, Innocent Besigye, Jacob S. Shabani, Martha Makwero   +4 more
doaj   +1 more source