Results 201 to 210 of about 583,563 (410)

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

open access: yesMolecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson   +11 more
wiley   +1 more source

'Glokal' litteraturhistoria – på väg mot en omvärdering av finlandssvensk barnlitteratur

open access: yesBarnboken: Tidskrift för Barnlitteraturforskning, 2011
This article considers the conditions and possibilities of writing a methodologically innovative glocal history of post-war Swedish-language children’s literature in Finland.
Österlund, Mia   +2 more
doaj  

Envisioning National Resources for Artificial Intelligence Research: NSF Workshop Report [PDF]

open access: yesarXiv
This is a report of an NSF workshop titled "Envisioning National Resources for Artificial Intelligence Research" held in Alexandria, Virginia, in May 2024. The workshop aimed to identify initial challenges and opportunities for national resources for AI research (e.g., compute, data, models, etc.) and to facilitate planning for the envisioned National ...
arxiv  

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu   +11 more
wiley   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

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