Results 51 to 60 of about 583,563 (410)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Mengungkap Struktur Permukiman Komunitas Akur (Adat Karuhun Urang) Cigugur Kabupaten Kuningan

Jurnal Pembangunan Wilayah dan Kota, 2020
The Karuhan Urang Indigenous Community (AKUR) Cigugur, West Java, is one of the traditional communities that still adheres to the Sunda Wiwitan belief. This community lives side by side with mutual respect for the views of other religions.
Imam Indratno, Ina H Agustina, Chusarini Chamid, Ansharsyah M Siddik, Sena H Kuntoro   +4 more
doaj   +1 more source

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

The Use of Public Data and Free Tools in National CSIRTs' Operational Practices: A Systematic Literature Review [PDF]

arXiv, 2023
Many CSIRTs, including national CSIRTs, routinely use public data, including open-source intelligence (OSINT) and free tools, which include open-source tools in their work. However, we observed a lack of public information and systematic discussions regarding how national CSIRTs use and perceive public data and free tools in their operational practices.
arxiv  

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Physicochemical Characterization, Antioxidant and Anticancer Activity Evaluation of an Acidic Polysaccharide from Alpinia officinarum Hance

Molecules
AHP-3a, a triple-helix acidic polysaccharide isolated from Alpinia officinarum Hance, was evaluated for its anticancer and antioxidant activities.
Huan Wen, Yangjun Kuang, Xiuxia Lian, Hailong Li, Mingyan Zhou, Yinfeng Tan, Xuguang Zhang, Yipeng Pan, Junqing Zhang, Jian Xu   +9 more
doaj   +1 more source

EU citizenship and the member states’ own competence regulating the conditions of obtaining or forfeiting national citizenship

Opolskie Studia Administracyjno-Prawne, 2020
The ability of a state to decide freely on the conditions of obtaining or forfeiting its national citizenship has always been perceived as a core element of sovereignty.
Marcin Pączek
doaj   +1 more source

Diffraction Patterns of Apertures Shaped as National Borders [PDF]

arXiv, 2022
How aesthetically pleasing is your country's diffraction pattern? This work summarizes the calculated and experimental Fraunhofer diffraction patterns obtained from using apertures lithographically formed into shapes of national borders. Calculations are made based on the fast Fourier transform of the aperture images.
arxiv  

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source