Results 51 to 60 of about 2,091,140 (221)

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Aulukluki neqkat: centering care of salmon and relational research in Indigenous fisheries in the Kuskokwim River, Alaska

Arctic Science
This Indigenous-led project aims to better understand historical and contemporary ways in which Alaska Native Peoples steward salmon and the values connected to salmon stewardship.
Janessa Esquible, Avery Hoffman, Danielle Lowrey, Destiny Ropati, Jacqueline Cleveland, Mike Williams, Jonathan Samuelson, Wilson Justin, Freddie Christiansen, Jessica Black, Rachel Donkersloot, Carrie Stevens, Brooke Woods, Dehrich Chya, Courtney Carothers   +14 more
doaj   +1 more source

Helicobacter pylori Infection and Markers of Gastric Cancer Risk in Alaska Native Persons: A Retrospective Case-Control Study

Canadian Journal of Gastroenterology and Hepatology, 2014
BACKGROUND: Alaska Native persons experience gastric cancer incidence and mortality rates that are three to four times higher than in the general United States population.
James W Keck, Karen M Miernyk, Lisa R Bulkow, Janet J Kelly, Brian J McMahon, Frank Sacco, Thomas W Hennessy, Michael G Bruce   +7 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Performance improvements and increased ruminal microbial interactions in Angus heifers via supplementation with native rumen bacteria during high-grain challenge

Scientific Reports
Feedlot cattle may be subjected to digestive disorders, including ruminal acidosis, due to high concentration of grain in their diet. Therefore, novel feeding strategies are required to maximize animal performance and mitigate economic losses in the ...
Fan Yang, Madison T. Henniger, Andrew S. Izzo, Emily A. Melchior, Brooke A. Clemmons, Mary A. Oliver, James R. Gaffney, Cameron Martino, Taylor B. Ault-Seay, Miranda L. Striluk, Jordan J. Embree, Juan F. Cordero-Llarena, Pierre-Yves Mulon, David E. Anderson, Mallory M. Embree, Phillip R. Myer   +15 more
doaj   +1 more source

Are We Seeking Pimatisiwin or Creating Pomewin? Implications for Water Policy

International Indigenous Policy Journal, 2012
The purpose of this discussion is to describe the worldview and sacred relationship of the Cree people in Alberta, as well as how colonial policy has created despair (pomewin) in Aboriginal communities and a state of disconnectedness from the water.
Patti LaBoucane-Benson, Ginger Gibson, Allen Benson, Greg Miller   +3 more
doaj   +1 more source

Assessment of heat stress induced alterations in polymorphonuclear (PMN) cell activity in native and crossbred cows

Journal of Applied Animal Research, 2020
Our current investigation was aimed to study differential influence of heat stress on defensive functions of blood polymorphonuclear cells among native and crossbred cows by culturing them in vitro after animal exposure to in vivo heat stress.
Veligatla Tejaswi, Balamurugan Balachander, Harry Abdul Samad, Mihir Sarkar, Vijay Prakash Maurya, Gynendra Singh   +5 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Changes in liver stiffness measurements following hepatitis C sustained virologic response among Alaska Native adults treated with sofosbuvir-based direct acting anti-viral therapy

International Journal of Circumpolar Health
Direct-acting antiviral (DAA) hepatitis C treatment can reduce fibrosis and prevent cirrhosis and its sequelae. This study aims to evaluate changes in fibrosis and lab measurements from pre-treatment to post-treatment and over time following the end-of ...
Janet M. Johnston, Lisa Townshend-Bulson, Brian McMahon, Dana Bruden, Chriss Homan, Kena Desai, Wileina Rhodes, Youssef Barbour   +7 more
doaj   +1 more source