Results 161 to 170 of about 2,748 (214)

Designer Dynamic DNA Nanoaggregate in Living Cell for Mitochondrial Energy Restriction

Advanced Science, EarlyView.
This study presents the Tech‐tetrahedron, a designer dynamic DNA nanoaggregate engineered for precise mitochondrial energy restriction. Its trinity‐functionalized design integrates navigable unit, telomerase‐activated latch, and self‐assembly module.
Ruijia Deng, Jing Sheng, Ben Niu, Wenjuan Fu, Yingjie Yang, Zuowei Xie, Shuang Xie, Yunxuan He, Meilin Gong, Jue Wang, Yan Pi, Ming Chen, Kai Chang   +12 more
wiley   +1 more source

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

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The fall of Native Fishes and the rise of Non-native Fishes in the Great Lakes Basin

Aquatic Ecosystem Health & Management, 2010
Over the last 200 years, the fish fauna of the Great Lakes has changed significantly as a result of declines in native species and the deliberate and inadvertent stocking of non-native fishes. These changes have resulted in the global extinction of three taxa and the extirpation of 18 species lowering the number of currently extant native species in ...
Nicholas E. Mandrak, B. Cudmore
openaire   +1 more source

Native Fish Conservation Areas: A Vision for Large-Scale Conservation of Native Fish Communities

Fisheries, 2011
Abstract The status of freshwater fishes continues to decline despite substantial conservation efforts to reverse this trend and recover threatened and endangered aquatic species. Lack of success is partially due to working at smaller spatial scales and focusing on habitats and species that are already degraded.
Jack E Williams, Richard N Williams, Russell F Thurow, Leah Elwell, David P Philipp, Fred A Harris, Jeffrey L Kershner, Patrick J Martinez, Dirk Miller, Gordon H Reeves, Christopher A Frissell, James R Sedell   +11 more
openaire   +1 more source

Functional Dimension Reveal Impacts of Non‐Native Fishes on Native Fishes and Ecosystem Functionality

Global Change Biology
ABSTRACTAnthropogenic‐mediated invasions of non‐native species are leading to biodiversity loss in many trophic groups, with specific impacts on a wide range of ecosystem functions and services. However, the impacts of non‐native species on native species and ecosystem multifunctionality are not well understood, particularly due to the lack of long ...
Zhice Liang, Donald A. Jackson, Jiashou Liu, Chuanbo Guo   +3 more
openaire   +2 more sources

Rough waters for native Chinese fish

Science, 2015
In the Policy Forum “China's aquaculture and the world's wild fisheries” (9 January, p. [133][1]), L. Cao et al. identify the increasing growth of aquaculture in China as potentially placing considerable pressure on global marine stocks.
openaire   +2 more sources

Contribution of native and non‐native species to fish communities in French reservoirs

Fisheries Management and Ecology, 2004
AbstractPrevious studies showed that only 20% of the variability in fish community structure in French reservoirs could be explained by site characteristics. In addition, no relationship was found between the relative abundance of species and stocking effort.
Irz, P., Argillier, Christine, Proteau, J.P.   +2 more
openaire   +1 more source

Non-native fishes and native species diversity in freshwater fish assemblages across the United States

Biological Invasions, 2008
The proliferation of non-native species in North American freshwater ecosystems is considered a primary threat to the integrity of native community structure. However, a general understanding of consistent and predictable impacts of non-native species on native freshwater diversity is limited, in part, because of a lack of broad-scale studies including
Alison L. Mitchell, Jason H. Knouft
openaire   +1 more source

Toxicity of endosulfan to native and introduced fish in Australia

Environmental Toxicology and Chemistry, 1992
AbstractSemistatic bioassays of endosulfan with native and introduced Australian fish indicated that they are sensitive to this insecticide at low concentrations. The introduced European carp (Cyprinus carpio) was the most sensitive species, with a measured 96-h LC50 of 0.1 μg/L, whereas the native eastern rainbow fish (Melanotaenia duboulayi) and ...
R.I.M. Sunderam, D.M.H. Cheng, G.B. Thompson   +2 more
openaire   +1 more source