Results 61 to 70 of about 2,432,930 (338)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Correspondence: When Human Understanding of Fish Invasion is Blurred [PDF]

, 2008
Leprieur et al.’s observation that fish invasions are blurred by human activity (Leprieur et al. 2008 doi:10.1371/journal.pbio.0060028) correctly reflected the well established understanding that fish invasion is human mediated (1-4).
Gozlan, Rodolphe Elie
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Phylogenetic and environmental DNA insights into emerging aquatic parasites: implications for risk management. [PDF]

, 2018
Species translocation leads to disease emergence in native species of considerable economic importance. Generalist parasites are more likely to be transported, become established and infect new hosts, thus their risk needs to be evaluated.
Andreou, Demetra, Blake, Adam, Davison, P, Hardouin, E.A., Paley, R., Pegg, Josie, Sana, Salma, Williams, C., Zhang, Tiantian   +8 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Multiple scales of biological variability in New Zealand streams : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Ecology at Massey University, Manawatū, New Zealand [PDF]

, 2016
Stream fish communities in Taranaki, New Zealand, were studied for the patterns and drivers of their spatial ecology. The study was focused on three main themes: a) complementarity between geography and landuse in driving regional distribution patterns ...
Jayasuriya
core  

Disturbance accumulation hampers fish assemblage recovery long after the worst mining spill in the Iberian Peninsula [PDF]

, 2016
The influence of environmental variables on native and exotic fish species richness and diversity was analysed 8 years after one of the most environmentally harmful toxic spills worldwide.
Aguiar, Bernardo, Borja, Burham, Clavero, Clavero, Corbacho, De Miguel, De Miguel, De Miguel, Doadrio, Elvira, Fernández-Delgado, Fernández-Delgado, Ferreira, Ferreira, Field, Gallart, Gasith, He, Herrera, Hughes, Johnson, Kaiser, Kopp, López-Pamo, Magalhaes, McArthur, Morán-López, Moyle, Márquez-Ferrando, Nikolsky, Olias, Pinto, Rico, Shannon, Sheldon   +36 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Documentation Related to a 1991 Observation of Sturgeon in the Rio Grande – Río Bravo, USA (Texas) and Mexico (Coahuila) [PDF]

, 2018
This digital archive provides a compilation of previously unpublished information regarding a 1991 observation of a live sturgeon (Family Acipenseridae) in the Rio Grande-Río Bravo of the USA and Mexico.
Cohen, Adam E., Hendrickson, Dean A., Platania, Steven P.   +2 more
core   +1 more source