Results 41 to 50 of about 449,411 (257)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Increased stability of a subtropic bamboo forest soil bacterial communities through integration of water and fertilizer management compared to conventional management

BMC Plant Biology
Background Conventional management (CM), substantial fertilization and flooding irrigation, has led to soil acidification, the decrease in soil bacterial diversity in bamboo forests.
Yi Li, Zacchaeus G. Compson, Xiaobao Kuang, Lin Yu, Qingni Song, Jun Liu, Dongmei Huang, Hanchang Zhou, Siyuan Huang, Ting Li, Qingpei Yang   +10 more
doaj   +1 more source

Comparison of a native and a non-native insular reptile species [PDF]

Journal of Tropical Ecology, 2015
Abstract:This study compared the life histories ofHemidactylus frenatus, a significant invasive gecko, andPhyllodactylus palmeus, a Honduran endemic, over 10 wk, June–August 2013 at 12 study sites on the Honduran island of Cayo Menor of the Cayo Cochinos archipelago whereH. frenatusarrived in 2008.
Nicholson, DJ, Hassall, C, Frazier, JA
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Integrated physiological unit (IPU) traits of Phyllostachys glauca McClure and their responses to habitat heterogeneity: Insights from 15N tracing

Advances in Bamboo Science
Running bamboo is a clonal plant group known for high utilization value and rapid range expansion. However, the integrated physiological unit (IPU), a fundamental physiological functional unit, remains poorly understood in running bamboo.
Shujin Wu, Longfeng Wang, Xuehua Ye, Zhan Shen, Shebao Yu, Na Zou, Hongying Yu, Jianmin Shi   +7 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Non-native and invasive tree species - their impact on biodiversity loss [PDF]

Zbornik Matice Srpske za Prirodne Nauke, 2018
The paper gives an overview of non-native and invasive tree species, and offers the basic data about their current presence in European forests.
Lakićević Milena D., Mladenović Emina M.   +1 more
doaj   +1 more source