Results 61 to 70 of about 443,957 (258)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Changes in Species Composition in Restored Wetland Habitat [PDF]

Geo Data
This study monitored of flora and fauna from 2022 to 2024 to investigate changes in biodiversity in relation to the wetland restoration project. A total of 220 plant species from 72 families and 141 animal species from 75 families were identified ...
Jeongseop An, Hyerin Yu, Cheol-Yeong Kim, Jieun Bak, Hae-jun Baek, Minjeong Seok, Youngho Cho, Soon Jae Eum, Youngjun Park, Dakyum Roh, Soo In Lee   +10 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Synthesis and crystal structure of methyl 4-(2-ethoxy-2-oxoethoxy)-3,5-dimethoxybenzoate, C14H18O7

Zeitschrift für Kristallographie - New Crystal Structures
C14H18O7, orthorhombic, P212121 (no. 19), a = 4.3538(6) Å, b = 12.7630(19) Å, c = 26.493(4) Å, V = 1,472.2(4) Å3, Z = 4, R gt(F) = 0.0414, wR ref (F 2) = 0.1043, T = 296(2) K.
Shang Xiao-ming, Luo Ying, Chen Nuo, Wang Zong-de, Luo Hai   +4 more
doaj   +1 more source

Quantitative Lipidomics Reveals Dynamic Lipid Profiles in Cinnamomum camphora Seed Kernels at Different Developmental Stages

Plants
Cinnamomum camphora seed kernels are a potentially valuable fatty oil resource; however, their lipid composition and dynamic changes during development remain poorly understood.
Han Xie, Yongjie Zheng, Yueting Zhang, Chenglin Luo, Ting Zhang, Wanwen Yu, Xuhui Zhang, Xinliang Liu   +7 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Synthesis and crystal structure of 4-(ethoxycarbonyl)phenyl 2-chloro-4-fluorobenzoate, C16H12ClFO4

Zeitschrift für Kristallographie - New Crystal Structures
C16H12ClFO4, monoclinic, P21, a = 12.2151(5) Å, b = 17.7534(12) Å, c = 13.8918(6) Å, β = 90.909(4)°, V = 3012.2(3) Å3, Z = 8, Rgt(F) = 0.0491, wRref(F2) = 0.1644, T = 296(2) K.
Ying Luo, Nuo Chen, Ming-Ming Liu, Zong-de Wang, Hai Luo   +4 more
doaj   +1 more source

Development and Validation of Species-Specific KASP and SCAR Markers for the Rapid Identification of the Endangered Orchid Calanthe aristulifera

Plants
Calanthe aristulifera is a critically endangered orchid species of profound horticultural and ecological significance. However, establishing its species integrity is complicated by frequent natural introgression with sympatric relatives, such as C ...
Jung Eun Hwang, Seongjun Kim, Hyeong Bin Park, Sung Min Han, Yubin Lee, Chang Woo Lee, Young-Joong Kim   +6 more
doaj   +1 more source