Results 131 to 140 of about 2,321,778 (225)

Pharmacokinetics and safety of a modified‐release psilocybin formulation: A SAD Phase I trial in normal‐weight and overweight/obese participants

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to evaluate the safety, tolerability and pharmacokinetics of a novel oral modified‐release psilocybin formulation (REL‐P11) in normal‐weight and overweight/obese healthy adults and to assess its suitability for controlled, subperceptual exposure, in light of emerging evidence supporting serotonergic modulation in metabolic ...
Anna Signor, Stefano Comai, Gianfranco Pasut, Franco Folli, Marco Gentilucci, Negar Gharavi, Sofia Raitsin, Thuy Van Nguyen, Marco Pappagallo, Andrea Mattarei, Paolo L. Manfredi, Sara De Martin   +11 more
wiley   +1 more source

A Behavior‐Integrated Potency Assay for Quantitative Evaluation of Extracellular Matrix Remodeling by Mesenchymal Stem/Stromal Cells

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Reliable potency assays are critical for ensuring the therapeutic consistency and manufacturing quality of mesenchymal stem/stromal cells (MSCs). Conventional assays based on soluble factor quantification often fail to capture extracellular matrix (ECM) remodeling capacity and exhibit high variability.
Shao Ying Tan, Mee‐Hae Kim, Masahiro Kino‐oka   +2 more
wiley   +1 more source

Utility of Native T1 Mapping for the Evaluation of Myocardial Iron Overload in Patients with Thalassemia Major. [PDF]

Tomography
Amadu AM, Contena A, Dessì A, Piscopo L, Solinas E, Turilli D, Fanni SC, Scaglione M, Masala S.   +8 more
europepmc   +1 more source

Correction: Myocardial native T₁ mapping and extracellular volume quantification in asymptomatic female carriers of Duchenne muscular dystrophy gene mutations. [PDF]

Orphanet J Rare Dis, 2023
Masárová L, Panovský R, Pešl M, Mary LM, Holeček T, Kincl V, Juříková L, Máchal J, Opatřil L, Feitová V.   +9 more
europepmc   +1 more source

Scale‐Down Platforms for Process‐Oriented Enzyme Screening Using Microfluidics

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Enzyme screening platforms are typically evaluated based on their throughput and analytical performance rather than their ability to mimic the conditions encountered at large scale. In bioreactors, enzymes experience gradients in substrate concentration, oxygen availability, pH, temperature, and interfacial exposure, caused by imperfect mixing
Maria I. Rodriguez‐Torres, Elif Erdem, Junhyeong Wang, Ulrich Krühne, Michael Daniele, John M. Woodley   +5 more
wiley   +1 more source

Protein thermal stability in the undergraduate biochemistry laboratory: Exploring protein thermal stability with yeast alcohol dehydrogenase

Biochemistry and Molecular Biology Education, Volume 53, Issue 2, Page 209-217, March/April 2025.
Abstract We created a novel laboratory experience where undergraduate students explore the techniques used to study protein misfolding, unfolding, and aggregation. Despite the importance of protein misfolding and aggregation diseases, protein unfolding is not typically explored in undergraduate biochemistry laboratory classes.
Alison Bates, Kathryn M. Williams, Ann E. Hagerman   +2 more
wiley   +1 more source

Quantitative native T1 mapping identifies papillary muscle and intracavitary cardiac lipomas: A multiparametric CMR case series. [PDF]

Radiol Case Rep
Montatore M, Rella M, Milo M, Masino F, Tupputi R, Fanigliulo G, Muscatella G, Testini V, Muscogiuri E, Guglielmi G.   +9 more
europepmc   +1 more source

Native T1-mapping and diffusion-weighted imaging (DWI) can be used to identify lung cancer pathological types and their correlation with Ki-67 expression. [PDF]

J Thorac Dis, 2022
Li G, Huang R, Zhu M, Du M, Zhu J, Sun Z, Liu K, Li Y.   +7 more
europepmc   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Customizing native T1 mapping: The effects of compressed sensing, deep learning-based denoising, and high-resolution on measurement of native myocardial T1. [PDF]

J Cardiovasc Magn Reson
Perazzolo A, Vita CV, Scialò V, Gamal M, Bruno E, Chao TC, Browne J, Demirel B, Waddle S, Leiner T.   +9 more
europepmc   +1 more source