Results 61 to 70 of about 404,926 (292)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Cities and the Environment, 2008 This paper discusses the reasoning behind the development of a new approach to designed urban planting with grasses, forbs and geophytes that has been undertaken at the University of Sheffield over the past 15 years.
James Hitchmough
doaj
European Journal for Research on the Education and Learning of Adults, 2017 The study described in this article used grounded theory methodology to investigate adults’ accounts of their relationships with others when using information and communication technologies (ICT). Ten women and ten men were interviewed. All were Italians
Rita Bencivenga
doaj +1 more source
Minority Newcomers: Fair Comparisons of Immigrants and the Native Born [PDF]
, 2003 Comparisons of the mostly "minority" foreign-born and mostly "white" native-born populations that fail to account for the socioeconomic impact of ethnicity incorrectly suggest that place of birth, rather than minority status, is the primary factor ...
Walter A. Ewing
core
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Complements or substitutes? Immigrant and native task specialization in Spain [PDF]
, 2008 Learning about the impact that immigration has on the labor market of the receiving nation is a topic of major concern, particularly in Spain, where immigration has more than doubled from 4 percent to roughly 10 percent of the population within a decade.
Amuedo-Dorantes, C., de la Rica, S.
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Implications of non-native species for mutualistic network resistance and resilience.
PLoS ONE, 2019 Resilience theory aims to understand and predict ecosystem state changes resulting from disturbances. Non-native species are ubiquitous in ecological communities and integrated into many described ecological interaction networks, including mutualisms. By
Clare E Aslan
doaj +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source