Results 41 to 50 of about 9,866 (257)

Natriuresis During an Acute Intravenous Sodium Chloride Infusion in Conscious Sprague Dawley Rats Is Mediated by a Blood Pressure-Independent α1-Adrenoceptor-Mediated Mechanism

Frontiers in Physiology, 2022
The mechanisms that sense alterations in total body sodium content to facilitate sodium homeostasis in response to an acute sodium challenge that does not increase blood pressure have not been fully elucidated.
Alissa A. Frame, Alissa A. Frame, Kayla M. Nist, Kayla M. Nist, Kiyoung Kim, Kiyoung Kim, Jill T. Kuwabara, Jill T. Kuwabara, Richard D. Wainford, Richard D. Wainford   +9 more
doaj   +1 more source

The exaggerated natriuresis of essential hypertension occurs independently of changes in renal medullary blood flow

Acta Physiologica, 2019
In patients with essential hypertension, abnormal renal sodium handling includes exaggerated natriuresis in response to extracellular volume expansion. We tested the hypothesis that exaggerated natriuresis is associated with increases in medullary and/or
K. Assersen, P. Høilund-Carlsen, M. Olsen, S. Greve, J. C. Gam-Hadberg, P. Braad, M. Damkjaer, P. Bie   +7 more
semanticscholar   +1 more source

Impaired pressure natriuresis and non‐dipping blood pressure in rats with early type 1 diabetes mellitus

Journal of Physiology, 2018
Type 1 diabetes mellitus increases cardiovascular risk; hypertension amplifies this risk, while pressure natriuresis regulates long‐term blood pressure.
G. Culshaw, Hannah M. Costello, D. Binnie, Kevin Stewart, A. Czopek, N. Dhaun, P. Hadoke, D. Webb, M. Bailey   +8 more
semanticscholar   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Urapidil: management of complicated hypertensive crises and effects on renal function. Therapeutist’s view

Кардиоваскулярная терапия и профилактика, 2012
Aim. To compare the effectiveness of urapidil and enalaprilat in cardiac patients with complicated hypertensive crise (HC), including the effect of the medications on renal function. Material and methods.
G. P. Arutyunov, L. G. Oganezova
doaj   +1 more source

Clinical Characteristics and Concordance of Anti‐MDA5 Antibodies: A Multicenter Australian Study

Arthritis Care &Research, EarlyView.
Objective In Australia, anti‐MDA5 antibodies are exclusively tested by a line immunoblot assay (LIA). The clinical concordance of an LIA‐positive anti‐MDA5 result is unclear. We aimed to describe the clinical features and determine the clinical concordance of patients with anti‐MDA5 antibodies. Methods Electronic records of a multisite cohort (patients
Syed B. Ali, Thomas Khoo, Keeran Shivakumar, Adam Caroll, Lauren Hender, Dimitra Beroukas, Kim Griggs, Celina Jin, Theo De Malmanche, Jessica Day, Gabor Major, Vidya Limaye   +11 more
wiley   +1 more source

Serum Soluble Urokinase Plasminogen Activator Receptor Levels in Resistant Hypertension

Turkish Journal of Nephrology
Background: Although the precise pathogenetic mechanisms remain incompletely elucidated, hypertension is characterized by endothelial damage and inflammation. The soluble urokinase plasminogen activator receptor (suPAR) is an inflammatory biomarker that
Nergiz Bayrakcı, Gülsüm Özkan, Sonat Pınar Kara, Ahsen Yılmaz, Aliye Çelikkol   +4 more
doaj   +1 more source

Intrarenal Hemodynamic Mechanisms of Kidney Protection by Nonsteroidal Mineralocorticoid Receptor Antagonists [PDF]

Endocrinology and Metabolism
Nonsteroidal mineralocorticoid receptor antagonists (nsMRAs), especially finerenone, have shown significant cardiorenal benefits in patients with chronic kidney disease (CKD).
Eun Sil Koh, So Young Lee, Doan Thi Thien Hao, Sungjin Chung   +3 more
doaj   +1 more source

Effects of Sodium-Glucose Cotransporter 2 Inhibitors on Water and Sodium Metabolism

Frontiers in Pharmacology, 2022
Sodium-glucose cotransporter 2 (SGLT2) inhibitors exert hypoglycemic and diuretic effects by inhibiting the absorption of sodium and glucose from the proximal tubule.
Jun Tang, Jun Tang, Lifang Ye, Lifang Ye, Qiqi Yan, Qiqi Yan, Xin Zhang, Xin Zhang, Lihong Wang, Lihong Wang   +9 more
doaj   +1 more source

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source