Results 311 to 320 of about 164,451 (332)

C-type Natriuretic Peptide: An Important Neuroendocrine Regulator?

Trends in Endocrinology & Metabolism, 2000
In the decade since its discovery, C-type natriuretic peptide (CNP), the third member of the natriuretic peptide family, has been shown to be produced by most of the major endocrine glands, including the hypothalamus and anterior pituitary. The relative abundance of its guanylyl cyclase-containing GC-B receptor in these glands suggests that CNP might ...
Robert C. Fowkes, Craig A. McArdle
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Cardiovascular and renal actions of C-type natriuretic peptide

American Journal of Physiology-Heart and Circulatory Physiology, 1992
Studies were performed in two groups of anesthetized dogs (n = 5 per group) to determine the cardiovascular and renal actions of synthetic C-type natriuretic peptide (CNP). Systemic infusion of CNP (group 1; 10 and 50 ng.kg-1.min-1 iv) resulted in marked cardiovascular hemodynamic effects characterized by a decrease in mean arterial pressure, cardiac ...
Alfredo L. Clavell, Lawrence L. Aarhus, John C. Burnett, A. J. Stingo   +3 more
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C-TYPE NATRIURETIC PEPTIDE (CNP) IN RATS AND HUMANS

Endocrinology, 1991
We have established a specific radioimmunoassay (RIA) for C-type natriuretic peptide (CNP), the third member of the natriuretic peptide family, and have elucidated its tissue distribution and molecular form. In rats, high concentrations of CNP-like immunoreactivity (-LI) were detected in the anterior lobe (19.8 +/- 8.6 pmol/g) and neurointermediate ...
Yoshihiro Ogawa, Shin Ichi Suga, Norio Hama, Masashi Mukoyama, Ichiro Kishimoto, Hiroshi Arai, Osamu Nakagawa, Yasato Komatsu, Gotaro Shirakami, Hiroo Imura, Kazuwa Nakao, Kiminori Hosoda   +11 more
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C-type natriuretic peptide system in rabbit oviduct

Peptides, 2001
C-type natriuretic peptide (CNP), a third member of the natriuretic peptide family, is known to be distributed mainly in brain and vascular endothelium and is considered to act as a local regulator in many tissues. The purpose of this study was to determine the presence of CNP system and its biological function in rabbit oviduct.
Kyung Woo Cho, Suhn Hee Kim, Kyung Hwan Seul, Sook Jeong Lee, Sung Zoo Kim, Kyung Sun Lee   +5 more
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Mechanism of relaxations to C-type natriuretic peptide in veins

American Journal of Physiology-Heart and Circulatory Physiology, 1996
C-type natriuretic peptide (CNP) is an endothelium-derived peptide that shares structural homology with atrial natriuretic peptide (ANP). CNP causes greater endothelium-independent relaxations in veins compared with arteries. Relaxations to CNP in porcine coronary arteries are mediated by hyperpolarization of the smooth muscle membrane.
Virginia M. Miller, Cheol H. Kim, Chi Ming Wei, John C. Burnett, Michelle Banks   +4 more
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C-type natriuretic peptide system in rabbit colon

Peptides, 2001
C-type natriuretic peptide (CNP) is mainly distributed in the brain and vascular endothelium and is considered to act as a local regulator in many tissues. The present study was aimed to determine the presence of CNP system and its biological function in rabbit colon.
Kyung Woo Cho, Sung Zoo Kim, Goan Hee Jeon, Jong Hun Kim, Suhn Hee Kim   +4 more
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C-type natriuretic peptide in vascular physiology and disease

Pharmacology & Therapeutics, 2005
Natriuretic peptides play a critical role in coordination of fluid/electrolyte balance and vascular tone. The renal effects of circulating atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are distinct from the paracrine effects of vascular C-type natriuretic peptide (CNP).
Amrita Ahluwalia, Ramona S. Scotland, Adrian J. Hobbs   +2 more
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Detection of C-type natriuretic peptide in fetal circulation

Journal of Perinatal Medicine, 2000
C-type natriuretic peptide (CNP) belongs to the natriuretic peptide family that plays an important role in the control of blood pressure, renal function and volume homeostasis. In contrast to the atrial natriuretic peptide and brain natriuretic peptide, CNP acts in an autocrine/paracrine fashion and is considered to be the endothelial component of the ...
Thomas Walther, Diego J. Walther, Holger Stepan, Renaldo Faber   +3 more
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C-type natriuretic peptide plasma levels are elevated in subjects with achondroplasia, hypochondroplasia, and thanatophoric dysplasia.

Journal of Clinical Endocrinology and Metabolism, 2015
CONTEXT C-type natriuretic peptide (CNP) is a crucial regulator of endochondral bone growth. In a previous report of a child with acromesomelic dysplasia, Maroteaux type (AMDM), caused by loss-of-function of the CNP receptor (natriuretic peptide receptor-
R. Olney, T. Prickett, E. Espiner, W. Mackenzie, Angela L. Duker, Colleen P. Ditro, B. Zabel, T. Hasegawa, H. Kitoh, A. Aylsworth, M. Bober   +10 more
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C-type natriuretic peptide in growth: A new paradigm

Growth Hormone & IGF Research, 2006
C-type natriuretic peptide (CNP), acting through its receptor, natriuretic peptide receptor-B (NPR-B), plays a critical role in linear growth. Knockout mice for CNP and NPR-B are dwarfed, and transgenic mice overexpressing CNP are overgrown. CNP has a direct regulatory effect on growth plate chondrocytes, acting primarily to promote terminal ...
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