Results 291 to 300 of about 990,536 (371)

Natriuretic peptides enhance the oxidative capacity of human skeletal muscle.

Journal of Clinical Investigation, 2012
S. Engeli, A. Birkenfeld, Pierre-Marie Badin, V. Bourlier, K. Louche, N. Viguerie, C. Thalamas, E. Montastier, D. Larrouy, I. Harant, I. de Glisezinski, S. Lieske, J. Reinke, Bibiana Beckmann, D. Langin, J. Jordan, C. Moro   +16 more
semanticscholar   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

The Impact of Natriuretic Peptides on Heart Development, Homeostasis, and Disease. [PDF]

Cells
Giovou AE, Gladka MM, Christoffels VM.
europepmc   +1 more source

Identification of congenital aortic valve malformations in juvenile natriuretic peptide receptor 2-deficient mice using high-frequency ultrasound

Vrushali Guruji, Yuqing Zhou, Mingyi Tang, Zahra Mirzaei, Yu Ding, Malak Elbatarny, Neda Latifi, Craig A. Simmons   +7 more
openalex   +2 more sources

An Unsuspected Property of Natriuretic Peptides: Promotion of Calcium-Dependent Catecholamine Release Via Protein Kinase G-Mediated Phosphodiesterase Type 3 Inhibition

Circulation, 2012
N. Y. Chan, N. Seyedi, Ken-ichi Takano, R. Levi   +3 more
semanticscholar   +1 more source

New biosensors and transgenic mice for multiplex cGMP imaging

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters, Martin Thunemann, Barbara Birk, Susanne Feil, Viacheslav O. Nikolaev, Moritz Lehners, Robert Feil   +6 more
wiley   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Osteocrin/musclin and the natriuretic peptides system: A novel focus in metabolism and cardiovascular prevention. [PDF]

Exp Physiol
Sarzani R, Landolfo M, Giulietti F, Spannella F.   +3 more
europepmc   +1 more source

B-type natriuretic peptide in patients after percutaneous trans-coronary-sinus mitral annuloplasty

, 2014
Tomasz Siminiak, Olga Jerzykowska, Michał Kuzemczak, Andrzej Szyszka, Piotr Kałmucki, Artur Baszko   +5 more
openalex   +2 more sources

Differential segment‐specific signalling pathways for guanylate cyclase C‐activated anion secretion in murine ileocolon

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu, Johannes Reiner, Franz Hofmann, Azam Salari, Ursula Seidler   +4 more
wiley   +1 more source