Results 151 to 160 of about 296,182 (247)

How do nanoparticle properties shape pharmacokinetics and pharmacodynamics? A mechanistic review. [PDF]

Front Pharmacol
Peralta-Cuevas E, Degollado-Hernández NY, Martínez-Ortiz IC, Gutierrez-Onofre AJ, Garcia-Atutxa I, Villanueva-Flores F.   +5 more
europepmc   +1 more source

In Situ Synthesis of Covalent Organic Frameworks Inside Cells for Triggering Ferroptosis and Immunotherapy

Advanced Materials, EarlyView.
We have developed an intracellular crystalline polymerization strategy involving acid‐catalyzed imine condensation to synthesize COFs in lysosomes. The generation of COFs in lysosomes damages their integrity, activates iron species, and induces immunogenic ferroptosis, thereby enhancing antitumor immunotherapy.
Qun Guan, Le‐Le Zhou, Zhiqing Yang, Yan‐An Li, Leyong Wang, Ruibing Wang   +5 more
wiley   +1 more source

Rainfall sustains multiyear La Niña. [PDF]

Nat Commun
Tian F, Zhang RH, Liu C, Guan C.
europepmc   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

mGem: Immune recognition and clearance of bacteriophages-implications for phage therapy. [PDF]

mBio
Le HT, Ahlenstiel G, Venturini C, Read SA.   +3 more
europepmc   +1 more source

Porous Hybrid Soft Actuators From Liquid Crystal Networks and Lyotropic Chromonic Liquid Crystal Templated Hydrogels

Advanced Materials, EarlyView.
The graphic illustrates the design of a hybrid bilayer composed of a liquid crystal hydrogel (LCH) and a liquid crystal network (LCN). The figure highlights the magnetic alignment of the chromonic hydrogel and the thermal‐responsive actuation of the LCN along with the LCH when both layers are aligned or misaligned, enabling programmable, light‐driven ...
Ramón Santiago Herrera Restrepo, Irving Hafed Tejedor García, Matthew Gene Scarfo, Negin Bouzari, Negar Rajabi, Olga Bantysh, Joel Torres‐Andrés, Christopher W. V. James, Maria Guix, Amirreza Aghakhani, Jordi Ignés‐Mullol, Salvador Pané, Josep Puigmartí‐Luis, Hamed Shahsavan   +13 more
wiley   +1 more source

Will animal reservoirs give us the next SARS-CoV-2 variant? [PDF]

PLoS Pathog
Smith D.
europepmc   +1 more source

A Biochar‐Based Composite Hydrogel Microenvironment for Enhanced Biocatalysis

Advanced Materials, EarlyView.
This work presents the synthesis of a polyacrylamide hydrogel wherein biomass‐derived biochar is co‐encapsulated with the enzyme horseradish peroxidase (HRP). The resulting composite hydrogel possesses balanced electron‐rich and electron‐deficient domains, creating an optimal microenvironment that concentrates both hydrogen peroxide and phenol ...
Shengzhe Wang, Jingling Zhu, Weiyang Xue, Yuting Wen, Zhongxing Zhang, Xia Song, Yuan Yu, Chenglin Sun, Huangzhao Wei, Jun Li   +9 more
wiley   +1 more source

<i>In situ</i> microseismicity reveals lithospheric accretion at the ultraslow-spreading Gakkel Ridge, Arctic Ocean. [PDF]

Natl Sci Rev
Yu Z, Li J, Ding W, Fang Y, Zhang T, Kong F, Jia Y, Niu X, Tan P, Liu Z, Lu Z.   +10 more
europepmc   +1 more source

Liquid Metal Microrobots for Magnetically Guided Transvascular Navigation

Advanced Materials, EarlyView.
Liquid metal‐based microrobots combine magnetic steering, intrinsic X‐ray visibility and softness, to navigate blood vessels even against flow. Under clinically relevant magnetic fields, liquid metal microrobots roll along vessel walls, cross endothelial barriers, and accumulate in target tissues.
Xiaohui Ju, Roshan Velluvakandy, Xianghua Wu, Miguel Angel Merlos Rodrigo, Zbyněk Heger, Kamila Bendíčková, Jan Frič, Martin Pumera   +7 more
wiley   +1 more source