Results 101 to 110 of about 7,944,445 (301)
Addressing economic barriers to crop diversification in rice-based cropping systems
npj Sustainable AgricultureCropping system diversification is widely promoted to address global challenges. However, its economic performance compared to high-yielding monoculture represents a major knowledge gap.
Sara Rosenberg +6 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Independent natural extension for sets of desirable gambles [PDF]
, 2011 We investigate how to combine a number of marginal coherent sets of desirable gambles into a joint set using the properties of epistemic irrelevance and independence.
De Cooman, Gert, Miranda, Enrique
core +1 more source
KEN: Kernel Extensions using Natural Language
, 2023 The ability to modify and extend an operating system is an important feature for improving a system's security, reliability, and performance. The extended Berkeley Packet Filters (eBPF) ecosystem has emerged as the standard mechanism for extending the Linux kernel and has recently been ported to Windows.
Zheng, Yusheng +3 more
openaire +2 more sources
TREX1, a predator for treating MSI‐H tumors?
Molecular Oncology, EarlyView.Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
, 2007 There is an attractive way to explain representation in terms of adaptivity: roughly, an item R represents a state of affairs S if it has the proper function of co-occurring with S (that is, if the ancestors of R co-occurred with S and this co-occurrence
Chrisley, Ron
core
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Gentzenizing Schroeder-Heister's natural extension of natural deduction.
Notre Dame Journal of Formal Logic, 1989 Our purpose here is to provide an example of how the use of the Gentzen-type sequential calculus considerably simplifies a complex Natural Deduction formalism. The formalism is that of Schroeder-Heister's system of higher-order rules. We show that the notions of Schroeder-Heister's that are the most difficult to handle become rebundant in the Gentzen ...
openaire +2 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source