Results 41 to 50 of about 721,379 (340)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

A Novel Method for Simplifying the Distribution Envelope of Green Tide for Fast Drift Prediction in the Yellow Sea, China

Remote Sensing
Since 2008, annual outbreaks of green tides in the Yellow Sea have had severe impacts on tourism, fisheries, water sports, and marine ecology, necessitating effective interception and removal measures.
Yi Ding, Song Gao, Guoman Huang, Lingjuan Wu, Zhiyong Wang, Chao Yuan, Zhigang Yu   +6 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Natural hazard and disaster tourism

Miscellanea Geographica: Regional Studies on Development, 2014
An observed trend, which can be defined as tourist interest in natural hazards and disasters, has persuaded the authors to attempt to research several issues, including tourist motivations and specific tourism properties and functions of this form of ...
Rucińska Dorota, Lechowicz Maciej
doaj   +1 more source

Present day challenges in understanding the geomagnetic hazard to national power grids [PDF]

, 2009
Power grids and pipeline networks at all latitudes are known to be at risk from the natural hazard of geomagnetically induced currents. At a recent workshop in South Africa, UK and South African scientists and engineers discussed the current ...
A.W.P. Thomson, B. Opperman, Bernhardi, Bolduc, Boteler, Boteler, C.M. Ngwira, C.T. Gaunt, Eastwood, Erinmez, J.A. Wild, Kappenman, Kappenman, L.-A. McKinnell, Lahtinen, Lanzerotti, Liu, Molinski, Ngwira, P. Cilliers, P. Kotze, Pirjola, Pirjola, Pulkkinen, Pulkkinen, S.I. Lotz, Thomson, Trichtchenko, Watari, Wik, Wintoft   +30 more
core   +4 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Cartographie du risque naturel dans le monde. Etude comparative entre une approche d’ordre social et une approche d’ordre économique de la vulnérabilité

Cybergeo, 2004
Since the last twenty years, natural hazard have taken an important place in our mind and in the media. Considered in the pastas the manifestation of the divine's anger and of the fatality, scientist progress has brought us to a rationalization of the ...
Gilles André
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source