Results 81 to 90 of about 721,379 (340)
The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential
Aging and Cancer, EarlyView.As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley +1 more source
Charity hazard - A real hazard to natural disaster insurance [PDF]
After the flooding in 2002 European governments provided billions of Euros of financial assistance to their citizens. Although there is no doubt that solidarity and some sort of assistance is reasonable, the question arises why these damages were not ...
Hannelore Weck-Hannemann, Paul Raschky
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Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao +10 more
wiley +1 more source
Scientific ReportsA numerical model is established based on the FVCOM-SWAVE wave-current coupling model to investigate the typhoon-induced wave and storm surge level in the southeastern coastal and offshore regions of China. A hindcast of 192 typhoons from 1979 to 2023 is
Yangyang Gao +3 more
doaj +1 more source
Customizing Reinsurance and Cat Bonds for Natural Hazard Risks [PDF]
This paper has the following two objectives: to examine how reinsurance coupled with new financial instruments can expand coverage to those residing in areas subject to catastrophic losses from natural disasters, and to show how reinsurance and the ...
David C. Croson, Howard C. Kunreuther
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A tale of two cities: Annapolis and St. Augustine balancing preservation and community values in an era of rising seas [PDF]
, 2020 Annapolis, Maryland, and St. Augustine, Florida, are colonial cities on the East Coast of the United States with national historic landmark designations recognizing the strong blends of natural and cultural resources that make each community unique ...
Craig, Lisa M., Keys, Leslee F.
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Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham +7 more
wiley +1 more source
Adaptive management of the climate change problem: bridging the gap between research and public policy [PDF]
There are important differences between adaptation to normal climate and adaptation to climate change. One scientific community is organized to address extreme probabilities in current distributions, and their disaster potential.
Săvoiu, Gheorghe
core +1 more source
Predicting uncertainty and risk in the natural sciences: bridging the gap between academics and industry [PDF]
, 2011 The increase in large-scale disasters in recent years, such as the 2007 floods in the UK, has caused disruptions of livelihood, enormous economic losses and increase in fatalities.
Franklin, Chris +4 more
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