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The Case for Natural History [PDF]
Science & Education, 2017 Fundamental knowledge of natural history is lacking in many western societies, as demonstrated by its absence in school science curricula. And yet, to meet local and global challenges such as environmental degradation, biodiversity loss and climate change, we need to better understand the living and non-living parts of the natural world.
Heather King, Marianne Achiam
openaire +5 more sources
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Scientific Reports, 2019 Molluscan eyes exhibit an enormous range of morphological variation, ranging from tiny pigment-cup eyes in limpets, compound eyes in ark clams and pinhole eyes in Nautilus, through to concave mirror eyes in scallops and the large camera-type eyes of the ...
Lauren Sumner-Rooney +3 more
doaj +1 more source
Hepatitis B virus infection--natural history and clinical consequences.
New England Journal of Medicine, 2004 This review article examines the structure and replication cycle of hepatitis B virus and discusses the natural history of primary infection, the mechanisms of clearance of the virus, and reasons for persistent infection.
D. Ganem, A. Prince
semanticscholar +1 more source
FEBS Letters, EarlyView.Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile +8 more
wiley +1 more source
Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes
FEBS Letters, EarlyView.Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley +1 more source
INHS Reports, Autumn 2006 [PDF]
, 2006 Cache River Watershed | INHS Research Assists Restoration Efforts in the Cache River Watershed | Warblers Provide Link Between Behavioral Ecology and Conservation Biology | Molecular Phylogeny of Cuerna Leafhoppers Suggest Hybridization | A Cache Full of
Illinois Natural History Survey
core
Molecular Oncology, EarlyView.This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti +10 more
wiley +1 more source
Approaches to estimating the universe of natural history collections data [PDF]
, 2010 This contribution explores the problem of recognizing and measuring the universe of specimen-level data existing in Natural History Collections around the world, in absence of a complete, world-wide census or register. Estimates of size seem necessary to
Ariño, Arturo H.
core +4 more sources
Epidemiology and natural history of inflammatory bowel diseases.
Gastroenterology, 2011 In the West, the incidence and prevalence of inflammatory bowel diseases has increased in the past 50 years, up to 8-14/100,000 and 120-200/100,000 persons, respectively, for ulcerative colitis (UC) and 6-15/100,000 and 50-200/100,000 persons ...
J. Cosnes +3 more
semanticscholar +1 more source