Results 111 to 120 of about 11,377,445 (319)
ZIKQ: An innovative centile chart method for utilizing natural history data in rare disease clinical development [PDF]
Utilizing natural history data as external control plays an important role in the clinical development of rare diseases, since placebo groups in double-blind randomization trials may not be available due to ethical reasons and low disease prevalence. This article proposed an innovative approach for utilizing natural history data to support rare disease
arxiv +1 more source
Natural History Specimen Collections [PDF]
, 2019 The Fish Collection described in this document was transferred in 1992 to the Fish Collection of the University of Texas at Austin in Austin (at that time administratively in the Texas Memorial Museum, but at the time of publication of this digital ...
Hildebrand, Henry H. +2 more
core +1 more source
Scientific ReportsWhile DNA barcoding methods are an increasingly important tool in biological conservation, the resource requirements of constructing reference libraries frequently reduce their efficacy.
William A Marsh +3 more
doaj +1 more source
A revision of the hitherto neglected genus Topiris Walker, 1863 (Lepidoptera, Xyloryctidae) with taxonomic notes on the genus Athrypsiastis Meyrick, 1910 [PDF]
ZooKeysThe genus Topiris Walker, 1863 is revised. This genus, previously neglected or deemed unrecognisable, comprised only Walker’s damaged and misrepaired type specimen of Topiris candidella Walker, 1863.
Mark J. Sterling +2 more
doaj +3 more sources
Natural history of infantile‐onset spinal muscular atrophy
Annals of Neurology, 2017 Infantile‐onset spinal muscular atrophy (SMA) is the most common genetic cause of infant mortality, typically resulting in death preceding age 2. Clinical trials in this population require an understanding of disease progression and identification of ...
S. Kolb +36 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
Consistent Histories as Valuations [PDF]
arXiv, 2013 Sorkin's coevent interpretation shifts the focus of quantum logic from the structure of a propositional lattice to the nature of truth valuations thereon. We apply this shift in emphasis to a simple formulation of the consistent histories approach, expressing it in terms of truth valuations which are brought together in a logical framework. We see that
arxiv
Natural selection. VII. History and interpretation of kin selection theory [PDF]
, 2013 Kin selection theory is a kind of causal analysis. The initial form of kin selection ascribed cause to costs, benefits, and genetic relatedness. The theory then slowly developed a deeper and more sophisticated approach to partitioning the causes of social evolution. Controversy followed because causal analysis inevitably attracts opposing views.
arxiv +1 more source
Immunity in natural history [PDF]
, 1996 Nobel Conference XXVIII. Lecture at Gustavus Adolphus College, October 1992.Includes bibliographical references (page 372).Immunity, involving a struggle for health, is also the defense of biological identity, and, in advanced species, of an idiographic ...
Rolston, Holmes, 1932-
core +1 more source
Natural history collections as windows on evolutionary processes
Molecular Ecology, 2016 Natural history collections provide an immense record of biodiversity on Earth. These repositories have traditionally been used to address fundamental questions in biogeography, systematics and conservation.
M. Holmes +10 more
semanticscholar +1 more source