Results 121 to 130 of about 12,326,405 (386)
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández +12 morewiley +1 more sourceTumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer
Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick +6 morewiley +1 more sourceHermeneutics and Nature [PDF]
, 2018 This paper contributes to the on-going research into the ways in which the humanities transformed the natural sciences in the late Eighteenth and early Nineteenth Centuries. By investigating the relationship between hermeneutics -- as developed by Herder Abu Zayd, Alexander, Alexander, Ankersmit, Apel, Assis, Ast, Augustine, Austin, Baird, Bakhtin, Bambach, Barnett, Barthes, Barthes, Barthes, Barthes, Barthes, Barthes, Barthes, Barthes, Barthold, Barton, Bauer, Bayer, Beck, Beiser, Benhabib, Berlin, Bernhardi, Bernhardi, Bernhardi, Bernstein, Betti, Betti, Binding, Blanke, Boeckh, Brandom, Brandom, Brentano, Brooks, Brooks, Bruns, Buckle, Buffon, Bultmann, Bultmann, Buntfuss, Bush, Byrne, Byrne, Byrne, Bödeker, Cassirer, Cassirer, Cassirer, Chakrabarty, Chomsky, Condillac, Corbin, Crowe, Dallmayr, Dannhauer, Daston, Davidson, Derrida, Derrida, Derrida, Detmer, Diderot, Diderot, Dilthey, Dilthey, Dilthey, Dilthey, Dilthey, Dilthey, Dilthey, Donagan, Donagan, Dray, Dronke, Droysen, Droysen, Droysen, Dryden, Dworkin, Elkins, Ermarth, Ernesti, Ernesti, Ernesti, Esterhammer, Evans, Feigl, Felski, Fichte, Fichte, Fichte, Fichte, Fichte, Fichte, Fichte, Figal, Findlay, Fish, Forster, Forster, Forster, Forster, Forster, Forster, Forster, Foucault, Foucault, Foucault, Foucault, Frank, Frank, Freud, Friedman, Gadamer, Gadamer, Gadamer, Gadamer, Gadamer, Gadamer, Gadamer, Gadamer, Gadamer, Gadamer, Gadamer, Gadamer, Gadamer, Gadamer, Galison, Gardiner, Gardner, Garfield, Gatterer, Gaukroger, Gentz, Gessinger, Girardot, Gjesdal, Gjesdal, Gjesdal, Glassius, Glock, Glock, Gordon, Graczyk, Grice, Grondin, Grotius, Grünbaum, Guignon, Guignon, Habermas, Habermas, Habermas, Habermas, Habermas, Habermas, Habermas, Habermas, Halbfass, Hamann, Hamann, Harbsmeier, Harbsmeier, Hardenberg, Hart, Hayes, Hegel, Hegel, Hegel, Hegel, Heidegger, Heidegger, Heidegger, Heidegger, Heidegger, Heidegger, Heidegger, Heidegger, Heidegger, Heidegger, Heidegger, Heidegger, Heidegger, Heidegger, Heidegger, Heidegger, Heidegger, Heidegger, Heidegger, Heidegger, Heidegger, Heidegger, Heidegger, Heidegger, Heidegger, Heidegger, Helmholtz, Herder, Herder, Herder, Herder, Herder, Herder, Herder, Herder, Herder, Herder, Herder, Herder, Herling, Heussi, Hirsch, Holborn, Horkheimer, Horkheimer, Horkheimer, How, Hoy, Hoy, Humboldt, Iggers, Iggers, Ingarden, Ingram, Irmscher, Jackson, Jauss, Jauss, Jellinek, Johnson, Jullien, Jäger, Kant, Kant, Keast, Keil, Keil, Kelletat, Kelsen, Kinzel, Kisiel, Kitcher, Kohler, Kohlstrunk, Kripke, Kristeva, Kuhn, Kümmel, Laband, Lamberton, Latour, Leiter, Lepore, Lewis, Lieber, Lin, Lopez, Lorenzer, Ma, Ma, Makeham, Makkreel, Makkreel, Malpas, Mandelbaum, Mannheim, Marchand, Margolis, Marmor, Marra, Martin, McCarthy, McCarthy, McKim, Mehta, Meinecke, Minnis, Misgeld, Mommsen, Moore, Moore, Moore, Moore, Moore, Moore, Moser, Nadler, Nassar, Neurath, Neuwirth, Nietzsche, Nietzsche, Nietzsche, Nietzsche, Nietzsche, Nietzsche, Nietzsche, Nietzsche, Nietzsche, Nietzsche, Nietzsche, Nisbet, Obert, Oexle, Orozco, Otto, Pitt, Plaks, Plaul, Pope, Pope, Popper, Porphyry, Poscher, Poscher, Ranke, Ranke, Ransom, Redding, Redding, Reichenbach, Reill, Reill, Reill, Reventlow, Reynolds, Ricœur, Ricœur, Ricœur, Ricœur, Ricœur, Ricœur, Ricœur, Roger, Ross, Rouse, Rouse, Rousseau, Runciman, Rupke, Rüsen, Rüsen, Sandys-Wunsch, Sartre, Sartre, Sartre, Sartre, Sauter, Savigny, Savigny, Schlegel, Schleiermacher, Schleiermacher, Schleiermacher, Schleiermacher, Schleiermacher, Schlink, Scholz, Schröter, Schröter, Seebohm, Seifert, Semler, Sheehan, Simmel, Sloan, Slocum, Solum, Sontag, Spinoza, Spinoza, Stadelmann, Stanley, Staël, Staël, Stern, Sullivan, Surber, Todorov, Troeltsch, Van Zoeren, Vasilache, Voltaire, Wach, Wach, Walsh, Wang, Warnke, Watkins, Weber, Weber, Weber, Weimar, Whittington, Windelband, Wittgenstein, Wittgenstein, Wittgenstein, Wolin, Wollheim, Wollheim, Wright, Wu, Wu, Zammito, Zammito, Zammito, Zhang, Zilsel, Zuckert +418 morecore +1 more sourceCytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén +13 morewiley +1 more sourceBiographical Sketch of Spencer Fullerton Baird [PDF]
, 1996 Spencer Fullerton Baird was born in Reading, Pennsylvania, February 3, 1823. In 1834 he was sent to a Quaker boarding-school kept by Dr. McGraw, at Port Deposit, Maryland, and the year following to the Reading Grammar School. In 1836 he entered Dickinson Goode, George Browncore Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma
Molecular Oncology, EarlyView.In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni +18 morewiley +1 more sourceThe tail of the Jurassic fish Leedsichthys problematicus (Osteichthyes: Actinopterygii) collected by Alfred Nicholson Leeds - an example of the importance of historical records in palaeontology [PDF]
, 2004 The specimen of the tail of <i>Leedsichthys problematicus</i>, now in The Natural History Museum, London, was one of the most spectacular fossil vertebrates from the Oxford Clay Formation of Peterborough, but as an isolated find it shares no ...HOFFSTETTER R., HUENE F., J. J. Liston, L. F. Noè, MARTILL D. M., MARTILL D. M., MICHELIS I., SMITH WOODWARD A., SMITH WOODWARD A., TORRENS H. S. +9 morecore +1 more source
