Results 141 to 150 of about 12,326,405 (386)
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
The text of Robert Boyle's 'Designe about natural history’ [PDF]
, 2008 This publication presents a new text of Robert Boyle’s prescriptions for the writing of natural history, compiled in 1666 and partially divulged in 1684, but unpublished till modern times.
Boyle, R.
core
Phenotype and animal domestication : A study of dental variation between domestic, wild, captive, hybrid and insular Sus scrofa [PDF]
, 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
Cucchi, Thomas +6 more
core +1 more source
Influence of homogenization methods on lichen species detection from environmental DNA metabarcoding [PDF]
Metabarcoding and MetagenomicsEnvironmental DNA (eDNA) techniques are increasingly employed in biodiversity monitoring of aquatic and terrestrial animals, plants, and fungi, holding great potential to revolutionize biodiversity assessments.
Ayumi Sakata +4 more
doaj +3 more sources
Decrypting cancer's spatial code: from single cells to tissue niches
Molecular Oncology, EarlyView.Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik +4 more
wiley +1 more source
International Journal of Adaptive Control and Signal Processing, EarlyView., 2023 Summary In this contribution, we propose a detailed study of interpolation‐based data‐driven methods that are of relevance in the model reduction and also in the systems and control communities. The data are given by samples of the transfer function of the underlying (unknown) model, that is, we analyze frequency‐response data.
Quirin Aumann, Ion Victor Gosea
wiley +1 more source
Why Study History? On Its Epistemic Benefits and Its Relation to the Sciences [PDF]
, 2017 I try to return the focus of the philosophy of history to the nature of understanding, with a particular emphasis on Louis Mink’s project of exploring how historical understanding compares to the understanding we find in the natural sciences.
Grimm, Stephen R.
core +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Hume's Natural Philosophy and Philosophy of Physical Science [PDF]
, 2020 This book contextualizes David Hume's philosophy of physical science, exploring both Hume's background in the history of early modern natural philosophy and its subsequent impact on the scientific ...
Slavov, Matias
core