Results 81 to 90 of about 4,890,231 (320)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Population genomic analyses of RAD sequences resolves the phylogenetic relationship of the lichen-forming fungal species Usnea antarctica and Usnea aurantiacoatra [PDF]
MycoKeys, 2018 Neuropogonoid species in the lichen-forming fungal genus Usnea exhibit great morphological variation that can be misleading for delimitation of species.
Felix Grewe +4 more
doaj +2 more sources
Ethnological collections from the North Pacific Coast of America [PDF]
, 1900 13 p. : ill.
American Museum of Natural History. +1 more
core
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Natural History Museum of Los Angeles [PDF]
The mission of the Natural History Museum of Los Angeles is to inspire wonder, discovery, and responsibility for our natural and cultural worlds. The Museum has three floors of exhibits, featuring the world’s largest collection of natural gold in the ...
core +2 more sources
Narrating the Natural History Unit: institutional orderings and spatial strategies [PDF]
, 2000 This paper develops a conceptualisation of institutional geographies through participation observation and interviews in the BBC's Natural History Unit (NHU), and the approach of actor network theory.
Davies, G
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
BMC Evolutionary Biology, 2017 Background Cylindrus obtusus is one of the most prominent endemic snail species of the Eastern Alps. It is restricted to alpine meadows and calcareous rocky habitats above 1500 m. Peculiar intraspecific differences have been observed in its genital tract
Luise Kruckenhauser +7 more
doaj +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Scientific ReportsWhile DNA barcoding methods are an increasingly important tool in biological conservation, the resource requirements of constructing reference libraries frequently reduce their efficacy.
William A Marsh +3 more
doaj +1 more source