Results 61 to 70 of about 2,326,817 (264)

Measuring Urban Resilience to Natural Hazards

TeMA: Journal of Land Use, Mobility and Environment, 2018
Natural disaster is an undeniable fact, and preparing to cope with and respond to it is an essential necessity. A resilient city can survive after a traumatic blow to its physical infrastructure, its economy, or its social fabric.
Mehrnaz Molavi
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Demographic profile of the “revolutionary turning point” generation of the Russian village in the first half of the 1920s

Вестник Тамбовского университета. Серия: Гуманитарные науки
Importance. The demographic portrait of peasantry in the first half of the 1920s is examined. The relevance of the study is due to the need for a comprehensive study of the Russian peasantry of the “revolutionary turning point” generation (born at the ...
V. A. Ippolitov, V. B. Bezgin
doaj   +1 more source

The nature of the increased peripheral resistance in hypertension∗ [PDF]

The American Journal of Cardiology, 1960
Abstract Studies on hypertension in both human beings and animals have shown an increased response to vasopressor and vasodepressor agents. This increased reactivity, as well as the incompleteness of vasodilatation by large doses of vasodepressor agents, is believed to be due to structural changes in the vascular tree.
openaire   +4 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Suitability of different plant pollens as supplementary food source and natural prey for predatory mite, Neoseiulus barkeri Hughes (Acari: Phytoseiidae)

گیاه‌پزشکی, 2019
Background and Objectives The predatory mite, Neoseiulus barkeri, is one of the most important biocontrol agents of the two-spotted spider mite Tetranychus urticae Koch or other pests.
M. Rezaie
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The Ethnic Make Up of the Population of Serbia – Census 2002

Migracijske i etničke teme, 2003
This article presents the ethnic structure of the population of Serbia (excluding Kosovo and Metohia), as well as that of Serbia proper and Vojvodina, according to the 2002 census results.
Nada Raduški
doaj